Evidence map›Paper›PMID 34371803›Full record

Trial reportNutrients2021

Pharmacodynamics of Oral Cholecalciferol in Healthy Individuals with Vitamin D Deficiency: A Randomized Open-Label Study.

Angelo Fassio, Davide Gatti, Maurizio Rossini, Camilla Benini, Elena Fracassi, Eugenia Bertoldo, Ombretta Viapiana, Stefano Milleri, Matteo Gatti, Giovanni Adami

Open access · goldAbstract readClinical Trial, Phase IRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Angelo FassioRheumatology Unit, University of Verona, 37134 Verona, Italy.
Davide GattiRheumatology Unit, University of Verona, 37134 Verona, Italy.ORCID 0000-0002-7471-3076
Maurizio RossiniRheumatology Unit, University of Verona, 37134 Verona, Italy.ORCID 0000-0001-9692-2293
Camilla BeniniRheumatology Unit, University of Verona, 37134 Verona, Italy.ORCID 0000-0002-8082-5023
Elena FracassiRheumatology Unit, University of Verona, 37134 Verona, Italy.
Eugenia BertoldoRheumatology Unit, University of Verona, 37134 Verona, Italy.
Ombretta ViapianaRheumatology Unit, University of Verona, 37134 Verona, Italy.
Stefano MilleriCentro Ricerche Cliniche di Verona, 37134 Verona, Italy.
Matteo GattiRheumatology Unit, University of Verona, 37134 Verona, Italy.
Giovanni AdamiRheumatology Unit, University of Verona, 37134 Verona, Italy.ORCID 0000-0002-8915-0755
University of Verona · IT

Funding

Abiogen Pharma The study was financially supported by an unrestricted grant from Abiogen Pharma, Pisa 339 Italy.
6 · The paper itself

Abstract

Comparative pharmacodynamic (PD) analyses on different dosing schedules for cholecalciferol supplementation are limited. This was an open-label, randomized, parallel-group study involving 75 healthy individuals deficient in vitamin D (baseline 25OHD < 20 ng/mL) receiving oral cholecalciferol with three different dosing regimens: Group A: 10,000 IU/day for 8 weeks followed by 1000 IU/day for 4 weeks; Group B: 50,000 IU/week for 12 weeks and Group C: 100,000 IU every other week for 12 weeks. Regulators of calcium and phosphate homeostasis, bone turnover markers and Wnt inhibitors were measured at baseline, Day 28, 53, 84, and 112. The 1,25OH2D increased at each time point. The increase was greater (

Indexed as

AdultBiomarkersBone RemodelingCalciumCholecalciferolFemaleFibroblast Growth Factor-23Healthy VolunteersHumansMaleMiddle AgedPhosphatesVitamin D DeficiencyVitaminsBiomarkersCalciumCholecalciferolFGF23 protein, humanFibroblast Growth Factor-23PhosphatesVitaminsbone turnover markerscholecalciferolosteoporosispharmacodynamicssupplementationvitamin D

Identifiers

PMID34371803
PMCPMC8308331
OpenAlexW3173412784

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.