Evidence map›Paper›PMID 34371785›Full record

ArticlePharmaceutics2021

Screening of Surfactants for Improved Delivery of Antimicrobials and Poly-Lactic-

Fiorenza Rancan, Jana Jurisch, Cemre Günday, Emre Türeli, Ulrike Blume-Peytavi, Annika Vogt, Christoph Schaudinn, Nazende Günday-Türeli

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Overview of Antimicrobial Biodegradable Polyester-Based Formulations.International journal of molecular sciences · 2023
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Fiorenza RancanResearch Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin 10117, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany.ORCID 0000-0003-3903-3240
Jana JurischResearch Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin 10117, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany.
Cemre GündayMyBiotech, 66802 Überherrn, Germany.ORCID 0000-0002-6653-8482
Emre TüreliMyBiotech, 66802 Überherrn, Germany.ORCID 0000-0003-0966-9352
Ulrike Blume-PeytaviResearch Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin 10117, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany.ORCID 0000-0003-3528-3752
Annika VogtResearch Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin 10117, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany.
Christoph SchaudinnAdvanced Light and Electron Microscopy (Zentrum für Biologische Gefahren und Spezielle Pathogene 4), Robert Koch Institute, 13353 Berlin, Germany.
Nazende Günday-TüreliMyBiotech, 66802 Überherrn, Germany.ORCID 0000-0002-6310-4785
Humboldt-Universität zu Berlin · DERobert Koch Institute · DE

Funding

Bundesministerium für Wirtschaft und Energie KF2088119MD4Bundesministerium für Wirtschaft und Energie KF2928204MD4Bundesministerium für Wirtschaft und Energie KF3409701MD4
6 · The paper itself

Abstract

Topical wound management is often a challenge due to the poor penetration of antimicrobials in wound tissue and across the biofilm matrix where bacteria are embedded. Surfactants have been used for decades to improve the stability of formulations, increase drug solubility, and enhance penetration. In this study, we screened different detergents with respect to their cytotoxicity and their ability to improve the penetration of poly-lactic-

Indexed as

antimicrobial deliverybiofilmnanoparticlesPseudomonas aeruginosawound infection

Identifiers

PMID34371785
PMCPMC8308990
OpenAlexW3184548807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.