ArticlePharmaceutics2021
Medicated Hydroxyapatite/Collagen Hybrid Scaffolds for Bone Regeneration and Local Antimicrobial Therapy to Prevent Bone Infections.
Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- 3D-printed multifunctional composite scaffolds incorporating copper ions/amoxicillin/hydroxyapatite for synergistic antibacterial and vascularized bone regeneration.Materials today. Bio · 2026Article
- Review
- From Wound Dressing to Tissue Regeneration: Bilayer Medicated Patches for Personalized Treatments of Chronic Wounds.ACS applied materials & interfaces · 2025Article
- Pioneering Soundscapes: Investigating Commercial Fused Deposition Modelling Filament's Potential for Ultrasound Technology in Bone Tissue Scaffolds.Bioengineering (Basel, Switzerland) · 2025Article
- Efficacy of Three-Dimensional Bioactive Composites in Long Bone Repair with Photobiomodulation.Materials (Basel, Switzerland) · 2025Article
- Application of Hydroxyapatite Composites in Bone Tissue Engineering: A Review.Journal of functional biomaterials · 2025Review
- Nanomaterial-mediated antibiotic delivery: a novel strategy for osteomyelitis therapy.Frontiers in bioengineering and biotechnology · 2025Review
- Antibiotics release by hybrid bone scaffold: relationship between kinetic profiles and scaffold intrinsic features.Frontiers in bioengineering and biotechnology · 2025Article
- Advances and Challenges in Polymer-Based Scaffolds for Bone Tissue Engineering: A Path Towards Personalized Regenerative Medicine.Polymers · 2024Review
- Nano-scaffold-based delivery systems of antimicrobial agents in the treatment of osteomyelitis ; a narrative review.Heliyon · 2024Review
- Development of Hybrid Implantable Local Release Systems Based on PLGA Nanoparticles with Applications in Bone Diseases.Polymers · 2024Article
- Advances in 3D printing technology for preparing bone tissue engineering scaffolds from biodegradable materials.Frontiers in bioengineering and biotechnology · 2024Article
- Collagen-hydroxyapatite based scaffolds for bone trauma and regeneration: recent trends and future perspectives.Nanomedicine (London, England) · 2024Review
- Complex Evaluation of Nanocomposite-Based Hydroxyapatite for Biomedical Applications.Biomimetics (Basel, Switzerland) · 2023Article
- Functionalization of biomimetic mineralized collagen for bone tissue engineering.Materials today. Bio · 2023Review
- Editorial for Special Issue: "Additive Manufacturing Approaches to Produce Drug Delivery Systems".Pharmaceutics · 2022Article
- Addressing the Needs of the Rapidly Aging Society through the Development of Multifunctional Bioactive Coatings for Orthopedic Applications.International journal of molecular sciences · 2022Review
- Conventional and Recent Trends of Scaffolds Fabrication: A Superior Mode for Tissue Engineering.Pharmaceutics · 2022Review
- Novel 3D Bioglass Scaffolds for Bone Tissue Regeneration.Polymers · 2022Article
- Biocompatibility Studies on a Collagen-Hydroxyapatite Biomaterial.Current health sciences journalArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microbial infections occurring during bone surgical treatment, the cause of osteomyelitis and implant failures, are still an open challenge in orthopedics. Conventional therapies are often ineffective and associated with serious side effects due to the amount of drugs administered by systemic routes. In this study, a medicated osteoinductive and bioresorbable bone graft was designed and investigated for its ability to control antibiotic drug release in situ. This represents an ideal solution for the eradication or prevention of infection, while simultaneously repairing bone defects. Vancomycin hydrochloride and gentamicin sulfate, here considered for testing, were loaded into a previously developed and largely investigated hybrid bone-mimetic scaffold made of collagen fibers biomineralized with magnesium doped-hydroxyapatite (MgHA/Coll), which in the last ten years has widely demonstrated its effective potential in bone tissue regeneration. Here, we have explored whether it can be used as a controlled local delivery system for antibiotic drugs. An easy loading method was selected in order to be reproducible, quickly, in the operating room. The maintenance of the antibacterial efficiency of the released drugs and the biosafety of medicated scaffolds were assessed with microbiological and in vitro tests, which demonstrated that the MgHA/Coll scaffolds were safe and effective as a local delivery system for an extended duration therapy-promising results for the prevention of bone defect-related infections in orthopedic surgeries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.