Evidence map›Paper›PMID 34371752›Full record

ArticlePharmaceutics2021

Repositioning of Tamoxifen in Surface-Modified Nanocapsules as a Promising Oral Treatment for Visceral Leishmaniasis.

Débora Faria Silva, Levi Eduardo Soares Reis, Marina Guimarães Carvalho Machado, Douglas Daniel Dophine, Vinicius Roberto de Andrade, Wanderson Geraldo de Lima, Margareth Spangler Andrade, José Mário Carneiro Vilela, Alexandre Barbosa Reis, Gwenaelle Pound-Lana and 2 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Débora Faria SilvaLaboratory of Clinical Research, Pharmacy School, Federal University of Ouro Preto, Ouro Preto 35400-000, Brazil.ORCID 0000-0002-8998-1233
Levi Eduardo Soares ReisLaboratory of Immunopathology, Post-Graduate Program in Biological Sciences, Federal University of Ouro Preto, Ouro Preto 35400-000, Brazil.ORCID 0000-0002-9924-8908
Marina Guimarães Carvalho MachadoLaboratory of Pharmaceutics and Nanotechnology, Pharmacy School, Federal University of Ouro Preto, Ouro Preto 35400-000, Brazil.
Douglas Daniel DophineLaboratory of Clinical Research, Pharmacy School, Federal University of Ouro Preto, Ouro Preto 35400-000, Brazil.ORCID 0000-0002-8738-6123
Vinicius Roberto de AndradeLaboratory of Clinical Research, Pharmacy School, Federal University of Ouro Preto, Ouro Preto 35400-000, Brazil.ORCID 0000-0002-4129-2922
Wanderson Geraldo de LimaLaboratory of Morphopathology, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto 35400-000, Brazil.ORCID 0000-0001-9844-3472
Margareth Spangler AndradeCenter-SENAI/CETEC, Laboratory of Nanoscopy, Belo Horizonte 31035-536, Brazil.
José Mário Carneiro VilelaCenter-SENAI/CETEC, Laboratory of Nanoscopy, Belo Horizonte 31035-536, Brazil.
Alexandre Barbosa ReisLaboratory of Immunopathology, Post-Graduate Program in Biological Sciences, Federal University of Ouro Preto, Ouro Preto 35400-000, Brazil.ORCID 0000-0001-8123-4164
Gwenaelle Pound-LanaLaboratory of Pharmaceutics and Nanotechnology, Pharmacy School, Federal University of Ouro Preto, Ouro Preto 35400-000, Brazil.ORCID 0000-0003-0569-0242
Simone Aparecida RezendeLaboratory of Clinical Research, Pharmacy School, Federal University of Ouro Preto, Ouro Preto 35400-000, Brazil.
Vanessa Carla Furtado MosqueiraLaboratory of Pharmaceutics and Nanotechnology, Pharmacy School, Federal University of Ouro Preto, Ouro Preto 35400-000, Brazil.ORCID 0000-0002-0368-6090
Universidade Federal de Ouro Preto · BRServiço Nacional de Aprendizagem Industrial · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Standards of care for human visceral leishmaniasis (VL) are based on drugs used parenterally, and oral treatment options are urgently needed. In the present study, a repurposing strategy was used associating tamoxifen (TMX) with polyethylene glycol-

Indexed as

drug releaseefficacyleishmaniasisnanocapsulePEG-PLAphysicochemical characterizationrepurposingtamoxifen

Identifiers

PMID34371752
PMCPMC8309129
OpenAlexW3179762751

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.