Evidence map›Paper›PMID 34371751›Full record

ArticlePharmaceutics2021

Effect of Carbon Chain Length, Ionic Strength, and pH on the In Vitro Release Kinetics of Cationic Drugs from Fatty-Acid-Loaded Contact Lenses.

Cesar Torres-Luna, Naiping Hu, Roman Domszy, Xin Fan, Jeff Yang, Robert M Briber, Nam Sun Wang, Arthur Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Cesar Torres-LunaDepartment of Chemical & Biomolecular Engineering, University of Maryland, College Park, MD 20740, USA.ORCID 0000-0003-4588-6880
Naiping HuLynthera Corporation, 1200 Corporate Blvd., STE 10C, Lancaster, PA 17601, USA.
Roman DomszyLynthera Corporation, 1200 Corporate Blvd., STE 10C, Lancaster, PA 17601, USA.
Xin FanDepartment of Chemical Engineering, Auburn University, Auburn, AL 36849, USA.ORCID 0000-0003-2615-7754
Jeff YangLynthera Corporation, 1200 Corporate Blvd., STE 10C, Lancaster, PA 17601, USA.
Robert M BriberDepartment of Materials Science & Engineering, University of Maryland, College Park, MD 20740, USA.
Nam Sun WangDepartment of Chemical & Biomolecular Engineering, University of Maryland, College Park, MD 20740, USA.
Arthur YangLynthera Corporation, 1200 Corporate Blvd., STE 10C, Lancaster, PA 17601, USA.
University of Maryland, College Park · USAuburn University · US

Funding

Maryland Industrial Partnerships No grant number
6 · The paper itself

Abstract

This paper explores the use of fatty acids in silicone hydrogel contact lenses for extending the release duration of cationic drugs. Drug release kinetics was dependent on the carbon chain length of the fatty acid loaded in the lens, with 12-, 14- and 18-carbon chain length fatty acids increasing the uptake and the release duration of ketotifen fumarate (KTF) and tetracaine hydrochloride (THCL). Drug release kinetics from oleic acid-loaded lenses was evaluated in phosphate buffer saline (PBS) at different ionic strengths (

Indexed as

biomaterialscationic drugdrug deliveryoleic acidsoft contact lensessustained releaseunsaturated fatty acid

Identifiers

PMID34371751
PMCPMC8309118
OpenAlexW3180467285

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.