Evidence map›Paper›PMID 34371695›Full record

ReviewPharmaceutics2021

Recent Advances in Liposomal-Based Anti-Inflammatory Therapy.

Carla M A van Alem, Josbert M Metselaar, Cees van Kooten, Joris I Rotmans

Open access · goldAbstract readReview
In one paragraph

Review in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Liposomes from red betel (Open veterinary journal · 2025
    Pooled it
  2. Polyphenol-Loaded Liposomal Nanocarriers fromMolecules (Basel, Switzerland) · 2026
    Article
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  18. Current Strategies and Potential Prospects for Nanoparticle-Mediated Treatment of Diabetic Nephropathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022
    Review
  19. Article
  20. Principles of Biocompatible Nanotube Design for High-Performance Biomaterials.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Carla M A van AlemDepartment of Internal Medicine, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Josbert M MetselaarInstitute for Experimental Molecular Imaging, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
Cees van KootenDepartment of Internal Medicine, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Joris I RotmansDepartment of Internal Medicine, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0001-9682-6234
Leiden University Medical Center · NLRWTH Aachen University · DE

Funding

Enceladus Pharmaceuticals NANederlandse Organisatie voor Wetenschappelijk Onderzoek 016.156.328
6 · The paper itself

Abstract

Liposomes can be seen as ideal carriers for anti-inflammatory drugs as their ability to (passively) target sites of inflammation and release their content to inflammatory target cells enables them to increase local efficacy with only limited systemic exposure and adverse effects. Nonetheless, few liposomal formulations seem to reach the clinic. The current review provides an overview of the more recent innovations in liposomal treatment of rheumatoid arthritis, psoriasis, vascular inflammation, and transplantation. Cutting edge developments include the liposomal delivery of gene and RNA therapeutics and the use of hybrid systems where several liposomal bilayer features, or several drugs, are combined in a single formulation. The majority of the articles reviewed here focus on preclinical animal studies where proof-of-principle of an improved efficacy-safety ratio is observed when using liposomal formulations. A few clinical studies are included as well, which brings us to a discussion about the challenges of clinical translation of liposomal nanomedicines in the field of inflammatory diseases.

Indexed as

administrationanti-inflammatoryformulationimmune systeminflammationinnovationliposomestherapy

Identifiers

PMID34371695
PMCPMC8309101
OpenAlexW3185130295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.