Evidence map›Paper›PMID 34371691›Full record

ReviewPharmaceutics2021

Hydroxycinnamic Acids and Derivatives Formulations for Skin Damages and Disorders: A Review.

Marco Contardi, Martina Lenzuni, Fabrizio Fiorentini, Maria Summa, Rosalia Bertorelli, Giulia Suarato, Athanassia Athanassiou

Open access · goldAbstract readReview
In one paragraph

Review in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 78 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Aspen PlusAntioxidants (Basel, Switzerland) · 2026
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. International journal of molecular sciences · 2024
    Article
  19. Article
  20. Comparison of Anti-Inflammatory and Antibacterial Properties ofInternational journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Marco ContardiSmart Materials, Italian Institute of Technology, 16163 Genoa, Italy.ORCID 0000-0003-3877-7985
Martina LenzuniSmart Materials, Italian Institute of Technology, 16163 Genoa, Italy.ORCID 0000-0002-2005-5389
Fabrizio FiorentiniSmart Materials, Italian Institute of Technology, 16163 Genoa, Italy.ORCID 0000-0001-8863-5286
Maria SummaTranslational Pharmacology, Italian Institute of Technology, 16163 Genoa, Italy.ORCID 0000-0002-8410-2607
Rosalia BertorelliTranslational Pharmacology, Italian Institute of Technology, 16163 Genoa, Italy.ORCID 0000-0002-7913-3564
Giulia SuaratoSmart Materials, Italian Institute of Technology, 16163 Genoa, Italy.
Athanassia AthanassiouSmart Materials, Italian Institute of Technology, 16163 Genoa, Italy.ORCID 0000-0002-6533-3231
Italian Institute of Technology · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alterations of skin homeostasis are widely diffused in our everyday life both due to accidental injuries, such as wounds and burns, and physiological conditions, such as late-stage diabetes, dermatitis, or psoriasis. These events are locally characterized by an intense inflammatory response, a high generation of harmful free radicals, or an impairment in the immune response regulation, which can profoundly change the skin tissue' repair process, vulnerability, and functionality. Moreover, diabetes diffusion, antibiotic resistance, and abuse of aggressive soaps and disinfectants following the COVID-19 emergency could be causes for the future spreading of skin disorders. In the last years, hydroxycinnamic acids and derivatives have been investigated and applied in several research fields for their anti-oxidant, anti-inflammatory, and anti-bacterial activities. First, in this study, we give an overview of these natural molecules' current source and applications. Afterwards, we review their potential role as valid alternatives to the current therapies, supporting the management and rebalancing of skin disorders and diseases at different levels. Also, we will introduce the recent advances in the design of biomaterials loaded with these phenolic compounds, specifically suitable for skin disorders treatments. Lastly, we will suggest future perspectives for introducing hydroxycinnamic acids and derivatives in treating skin disorders.

Indexed as

anti-bacterialanti-inflammatoryanti-oxidantsbiomaterialshydroxycinnamic acidsskin careskin disorders

Identifiers

PMID34371691
PMCPMC8309026
OpenAlexW3180555301

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.