Evidence map›Paper›PMID 34371271›Full record

ArticleMultiple sclerosis and related disorders2021

Liver kinase B1 rs9282860 polymorphism and risk for multiple sclerosis in White and Black Americans.

Anne I Boullerne, Mitchell T Wallin, William J Culpepper, Heidi Maloni, Elizabeth A Boots, Dagmar M Sweeney, Douglas L Feinstein

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis and related disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Anne I BoullerneDepartment of Anesthesiology, University Illinois, Chicago, IL, USA.
Mitchell T WallinVA Multiple Sclerosis Center of Excellence-East, Washington, DC, USA; George Washington University School of Medicine in Washington, DC, USA; Department of Neurology, University Maryland, Baltimore, MD, USA.
William J CulpepperVA Multiple Sclerosis Center of Excellence-East, Washington, DC, USA; Department of Neurology, University Maryland, Baltimore, MD, USA.
Heidi MaloniVA Multiple Sclerosis Center of Excellence-East, Washington, DC, USA.
Elizabeth A BootsDepartment of Psychology, University Illinois, Chicago, IL, USA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL.
Dagmar M SweeneyResearch Resources Center, University Illinois, Chicago, IL, USA.
Douglas L FeinsteinDepartment of Anesthesiology, University Illinois, Chicago, IL, USA; Jesse Brown VA Medical Center, Chicago, IL, USA, USA. Electronic address: dlfeins@uic.edu.
University of Illinois Chicago · USGeorge Washington University · USMultiple Sclerosis Center of Atlanta · USUniversity of Maryland, Baltimore · US

Funding

Liver Kinase B1, a genetic risk factor for multiple sclerosisI01BX002625 · VA · JESSE BROWN VA MEDICAL CENTER · PI FEINSTEIN, DOUGLAS L. · 2016 to 2023
–
BLR&D Research Career Scientist Award ApplicationIK6BX004852 · VA · JESSE BROWN VA MEDICAL CENTER · PI Douglas L. Feinstein · 2020 to 2026
–
BLRD VA I01 BX002625BLRD VA IK6 BX004852
6 · The paper itself

Abstract

backgroundWe previously reported that the single nucleotide polymorphism (SNP) rs9282860 in serine threonine kinase 11 (STK11) gene which codes for liver kinase B1 (LKB1) has higher prevalence in White relapsing-remitting multiple sclerosis (RRMS) patients than controls. However it is not known if this SNP is a risk factor for MS in other populations.

methodsWe assessed the prevalence of the STK11 SNP in samples collected from African American (AA) persons with MS (PwMS) and controls at multiple Veterans Affairs (VA) Medical Centers and from a network of academic MS centers. Genotyping was carried out using a specific Taqman assay. Comparisons of SNP frequencies were made using Fisher's exact test to determine significance and odds ratios. Group means were compared by appropriate t-tests based on normality and variance using SPSS V27.

resultsThere were no significant differences in average age at first symptom onset, age at diagnosis, disease duration, or disease severity between RRMS patients recruited from VAMCs versus non-VAMCs. The SNP was more prevalent in AA than White PwMS, however only in secondary progressive MS (SPMS) patients was that difference statistically significant. AA SPMS patients had higher STK11 SNP prevalence than controls; and in that cohort the SNP was associated with older age at symptom onset and at diagnosis.

conclusionsThe results suggest that the STK11 SNP represents a risk factor for SPMS in AA patients, and can influence both early (onset) and later (conversion to SPMSS) events.

Indexed as

Multiple SclerosisMultiple Sclerosis, Chronic ProgressiveMultiple Sclerosis, Relapsing-RemittingAgedBlack or African AmericanHumansLiverPolymorphism, Single NucleotideProtein Serine-Threonine KinasesProtein Serine-Threonine KinasesAfrican AmericanMilitary VeteransMultiple sclerosisProgressive formrace and ethnicitySNP

Identifiers

PMID34371271
PMCPMC9020467
OpenAlexW3191476305

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.