Evidence map›Paper›PMID 34371184›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2021

METTL1/WDR4-mediated m

Jieyi Ma, Hui Han, Ying Huang, Chunlong Yang, Siyi Zheng, Tiancai Cai, Jiong Bi, Xiaohui Huang, Ruiming Liu, Libin Huang and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 184 papers.

0numbers the graph read from it
0cells of the map it votes in
184citing papers in PubMed
16.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

184 citing papers in PubMed, 257 citations in OpenAlex.

  1. Article
  2. Adenosine 5'-Carboxamide-Based Inhibitors of METTL1.ACS medicinal chemistry letters · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. METTL1-mediated mOncogene · 2026
    Article
  10. Review
  11. Review
  12. METTL1-Mediated MAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  13. Article
  14. Review
  15. RNA modification systems as therapeutic targets.Nature reviews. Drug discovery · 2026
    Review
  16. Article
  17. METTL1-Mediated NMedComm · 2026
    Article
  18. Review
  19. Article
  20. Review

124 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Jieyi MaLaboratory of General Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China; Center for Translational Medicine, Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Hui HanCenter for Translational Medicine, Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Ying HuangDepartment of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Chunlong YangCenter for Translational Medicine, Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Siyi ZhengCenter for Translational Medicine, Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Tiancai CaiXiamen Special Service Convalescent Center, Xiamen 361005, China.
Jiong BiLaboratory of General Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Xiaohui HuangLaboratory of General Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Ruiming LiuLaboratory of General Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Libin HuangDepartment of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Yifeng LuoDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China. Electronic address: lyif@mail.sysu.edu.cn.
Wen LiLaboratory of General Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. Electronic address: liwen@mail.sysu.edu.cn.
Shuibin LinCenter for Translational Medicine, Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou 510060, China. Electronic address: linshb6@mail.sysu.edu.cn.
Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mis-regulated epigenetic modifications in RNAs are associated with human cancers. The transfer RNAs (tRNAs) are the most heavily modified RNA species in cells; however, little is known about the functions of tRNA modifications in cancers. In this study, we uncovered that the expression levels of tRNA N

Indexed as

Lung NeoplasmsProtein BiosynthesisCodon UsageGTP-Binding ProteinsHumansMethyltransferasesRNA, TransferGTP-Binding ProteinsMethyltransferasesMETTL1 protein, humanRNA, TransferWDR4 protein, humanlung cancerm(7)GMETTL1N(7)-methylguanosinetranslationtRNA modificationWDR4

Identifiers

PMID34371184
PMCPMC8636169
OpenAlexW3188557385

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.