ArticleBrain, behavior, and immunity2021
B-cells are abnormal in psychosocial stress and regulate meningeal myeloid cell activation.
Article in Brain, behavior, and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- Infantile Cocktail of Erythropoietin and Melatonin Restores Gait in Adult Rats with Preterm Brain Injury.Developmental neuroscience · 2022Trial
- Differential expression of lymphocyte markers by neighborhood opportunity among US adults: Insights from the Midlife in the United States study.Psychoneuroendocrinology · 2026Article
- Discrimination exposure and lymphocyte differentiation: Results from the health and retirement study.Brain, behavior, & immunity - health · 2026Article
- Meningeal immunity and "Interstitial" therapy: a new paradigm for immunotherapy in glioblastoma.Frontiers in immunology · 2026Review
- Brain-specific immune hub activation in paediatric focal lesional epilepsy: a case-control study.Brain communications · 2026Article
- Study on the cognitive effects of eye movement desensitization and reprocessing: proposed active mechanisms.Frontiers in computational neuroscience · 2026Article
- Gut irradiation and microbiota status modulate the meningeal immune landscape.Discovery immunology · 2026Article
- Immunometabolic reprogramming of central and peripheral immune cells in mental disorders: mechanisms and therapeutic implications.Frontiers in immunology · 2026Review
- Inflammatory profiles of transdiagnostic symptom dimensions in healthy females.Brain, behavior, & immunity - health · 2025Article
- Re-Examination of Inflammation in Major Depressive Disorder: Bridging Systemic and Neuroinflammatory Insights.Biomolecules · 2025Review
- The multifaceted impact of stress on immune function.Molecular biology reports · 2025Review
- Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling in male mice.Nature communications · 2025Article
- B cells in non-lymphoid tissues.Nature reviews. Immunology · 2025Review
- Extra-axial inflammatory signal and its relationship to peripheral and central immunity in depression.Brain : a journal of neurology · 2025Article
- The immunological perspective of major depressive disorder: unveiling the interactions between central and peripheral immune mechanisms.Journal of neuroinflammation · 2025Review
- Immune conversations at the border: meningeal immunity in health and disease.Frontiers in immunology · 2025Review
- Gene signatures associated with exosomes as diagnostic markers of postpartum depression and their role in immune infiltration.Frontiers in endocrinology · 2025Article
- Role of meningeal immunity in brain function and protection against pathogens.Journal of inflammation (London, England) · 2024Review
- B cells and the stressed brain: emerging evidence of neuroimmune interactions in the context of psychosocial stress and major depression.Frontiers in cellular neuroscience · 2024Review
- Current views on meningeal lymphatics and immunity in aging and Alzheimer's disease.Molecular neurodegeneration · 2023Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
There is increasing interest in how immune cells, including those within the meninges at the blood-brain interface, influence brain function and mood disorders, but little data on humoral immunity in this context. Here, we show that in mice exposed to psychosocial stress, there is increased splenic B cell activation and secretion of the immunoregulatory cytokine interleukin (IL)-10. Meningeal B cells were prevalent in homeostasis but substantially decreased following stress, whereas Ly6C
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.