ReviewAlcohol (Fayetteville, N.Y.)2022
Structural, functional, and behavioral significance of sex and gonadal hormones in the basolateral amygdala: A review of preclinical literature.
Review in Alcohol (Fayetteville, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Social isolation recruits amygdala-medial prefrontal cortex projections to escalate alcohol drinking in male mice.Nature neuroscience · 2026Article
- Sex differences in low-dose ethanol effects on motivated behavior and limbic corticostriatal activity in mice.Alcohol, clinical & experimental research · 2026Article
- Sex Differences in Low-dose Ethanol Effects on Motivated Behavior and Limbic Corticostriatal Activity.bioRxiv : the preprint server for biology · 2025Article
- Behavioral and Brain Gene and Protein Changes in Female Mice Consuming Ethanol During Pregnancy and Lactation.Biomolecules · 2025Article
- Sex differences in the microglial response to stress and chronic alcohol exposure in mice.Biology of sex differences · 2025Article
- Sex and sobriety: Human brain structure and function in AUD abstinence.Alcohol (Fayetteville, N.Y.) · 2024Review
- Sex differences in neural response to an acute stressor in individuals with an alcohol use disorder.Alcohol, clinical & experimental research · 2024Article
- Basolateral amygdala neuropeptide Y system modulates binge ethanol consumption.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Neurosteroids: mechanistic considerations and clinical prospects.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Inhibition of Estradiol Signaling in the Basolateral Amygdala Impairs Extinction Memory Recall for Heroin-Conditioned Cues in a Sex-Specific Manner.Neuroendocrinology · 2024Article
- Acute Ethanol Modulates Synaptic Inhibition in the Basolateral Amygdala via Rapid NLRP3 Inflammasome Activation and Regulates Anxiety-Like Behavior in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Astrocyte expression in the extended amygdala of C57BL/6J mice is sex-dependently affected by chronic intermittent and binge-like ethanol exposure.Alcohol (Fayetteville, N.Y.) · 2023Article
- The Track-by-Day Method for Monitoring the Rodent Estrous Cycle.Current protocols · 2023Article
- Sex differences in stress-induced alcohol intake: a review of preclinical studies focused on amygdala and inflammatory pathways.Psychopharmacology · 2022Review
- Estradiol and Estrogen-like Alternative Therapies in Use: The Importance of the Selective and Non-Classical Actions.Biomedicines · 2022Review
- HPA axis dysfunction during morphine withdrawal in offspring of female rats exposed to opioids preconception.Neuroscience letters · 2022Article
- Prenatal maternal stress and offspring aggressive behavior: Intergenerational and transgenerational inheritance.Frontiers in behavioral neuroscience · 2022Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The basolateral amygdala (BLA) is intimately involved in the development of neuropsychiatric disorders such as anxiety and alcohol use disorder (AUD). These disorders have clear sex biases, with women more likely to develop an anxiety disorder and men more likely to develop AUD. Preclinical models have largely confirmed these sex-specific vulnerabilities and emphasize the effects of sex hormones on behaviors influenced by the BLA. This review will discuss sex differences in BLA-related behaviors and highlight potential mechanisms mediated by altered BLA structure and function, including the composition of GABAergic interneuron subpopulations, glutamatergic pyramidal neuron morphology, glutamate/GABA neurotransmission, and neuromodulators. Further, sex hormones differentially organize dimorphic circuits during sensitive developmental periods (organizational effects) and initiate more transient effects throughout adulthood (activational effects). Current literature indicates that estradiol and allopregnanolone, a neuroactive progestogen, generally reduce BLA-related behaviors through a variety of mechanisms, including activation of estrogen receptors or facilitation of GABA
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.