Evidence map›Paper›PMID 34371102›Full record

Trial reportJournal of the American Academy of Child and Adolescent Psychiatry2022

Adaptive Treatment for Youth With Substance Use and Depression: Early Depression Response and Short-term Outcomes.

John F Curry, Yifrah Kaminer, David B Goldston, Grace Chan, Karen C Wells, Rebecca H Burke, Adrienne Banny Inscoe, Allison E Meyer, Shayna M Cheek

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Academy of Child and Adolescent Psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02227589 (Treatment for Teens With Alcohol Abuse and Depression), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02227589 nacompletednot on this map

Treatment for Teens With Alcohol Abuse and Depression

TypeinterventionalSponsorDuke UniversityRan2015 to 2020Enrolled103ConditionsAOD Use, Abuse, and Dependence, DepressionArmsMET/CBT-12, CBT-D, D-TAU
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

John F CurryDuke University School of Medicine, Durham, North Carolina. Electronic address: john.curry@duke.edu.
Yifrah KaminerAlcohol Research Center, University of Connecticut, Farmington.
David B GoldstonDuke University School of Medicine, Durham, North Carolina.
Grace ChanAlcohol Research Center, University of Connecticut, Farmington.
Karen C WellsDuke University School of Medicine, Durham, North Carolina.
Rebecca H BurkeUConn School of Medicine, Farmington, Connecticut.
Adrienne Banny InscoeDuke University School of Medicine, Durham, North Carolina.
Allison E MeyerAt the time of the study, Duke University, Durham, North Carolina; University of Michigan, Ann Arbor, Michigan.
Shayna M CheekDuke University, Durham, North Carolina.
Duke University · USInstitute of Alcohol Studies · GBUConn Health · USUniversity of Michigan · US

Funding

Treatment of Co-Occurring Alcohol Use Disorders and Depression/Anxiety DisordersR01AA021735 · NIAAA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HESSELBROCK, VICTOR M, KAMINER, YIFRAH · 2014 to 2018
$1.9M
Treatment for Teens with Alcohol Abuse and DepressionR01AA021719 · NIAAA · DUKE UNIVERSITY · PI GOLDSTON, DAVID B. · 2014 to 2018
$1.4M
NIAAA NIH HHS R01 AA021719NIAAA NIH HHS R01 AA021735
6 · The paper itself

Abstract

objectiveTo investigate prevalence and predictors of early depression response (EDR) in adolescents with substance use and depression receiving cognitive-behavioral therapy (CBT) for substance use and to test the efficacy of supplemental CBT targeting depression (CBT-D) for non-EDR adolescents in an adaptive treatment approach.

methodAt 2 sites, 95 youths (ages 14-21, mean [SD] = 17.4 [1.8]) with alcohol or cannabis use and depressive symptoms received up to 12 sessions of CBT for substance use over 14 weeks. Assessments were at baseline and weeks 4, 9, and 14. The Children's Depression Rating Scale-Revised was the primary depression measure, with a reduction of 50% or more on this scale at week 4 defining EDR. The primary substance use outcomes of alcohol use, heavy alcohol use, and cannabis use frequency were assessed via interview report on the Alcohol Consumption Questionnaire and the Drug Checklist. Urinalysis provided a secondary measure of cannabis use. Non-EDR adolescents were randomly assigned to supplemental CBT-D or enhanced treatment as usual (ETAU).

resultsThirty-five adolescents (37%; 95% CI, 27%-47%) demonstrated EDR. Fewer days of cannabis use (odds ratio 0.977; 95% CI, 0.961-0.992) and absence of conduct disorder (odds ratio 0.149; 95% CI, 0.031-0.716) predicted EDR. Frequency of drinking (F

conclusionApproximately one-third of adolescents with substance use and depression attain EDR during substance use treatment. Less frequent cannabis use facilitates depression response. The relatively small sample may have precluded identification of additional EDR predictors. CLINICAL TRIAL REGISTRATION INFORMATION: Treatment for Teens With Alcohol Abuse and Depression; https://clinicaltrials.gov/; NCT02227589.

Indexed as

CannabisCognitive Behavioral TherapySubstance-Related DisordersAdolescentAdultChildDepressionHumansTreatment OutcomeYoung Adultadaptive treatmentadolescencecognitive-behavioral therapydepressionsubstance use

Identifiers

PMID34371102
PMCPMC8818057
OpenAlexW3189323492

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.