ArticlePloS one2021
Dynamic physiological responses in obese and non-obese adults submitted to cardiopulmonary exercise test.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Insulin resistance and metabolic health predict cardiorespiratory fitness: cohort study.European heart journal open · 2026Article
- Peak oxygen consumption as a modifier of the obesity paradox in patients with obesity with heart failure with reduced ejection fraction.International journal of obesity (2005) · 2026Article
- Inter-individual variability in physiological adaptations during heat acclimation in adults: Contributions of body mass index and body size.Physiological reports · 2026Article
- Initial Implementation and Utilization of Cardiopulmonary Exercise Testing at a Pulmonary Department of an Academic Tertiary Care Center: An Overview.Journal of clinical medicine · 2025Article
- Invasive Cardiopulmonary Exercise Testing in Chronic Thromboembolic Pulmonary Disease; Obesity and the VJournal of clinical medicine · 2024Article
- A detailed analysis of body composition in relation to cardiopulmonary exercise test indices.Scientific reports · 2024Article
- Cardiopulmonary exercise testing and body composition.ERJ open research · 2024Article
- Characteristics of cardiopulmonary exercise capacity in adults with different degrees of obesity.Frontiers in physiology · 2024Article
- Heart Rate Responses at Rest, during Exercise and after Exercise Periods in Relation to Adiposity Levels among Young Nigerian Adults.Journal of obesity & metabolic syndrome · 2023Article
- Obesity and Body Mass Components Influence Exercise Tolerance and the Course of Hypertension in Perimenopausal Women.Journal of cardiovascular development and disease · 2022Article
- Cardiorespiratory fitness as a mediator in the relationship between lung function and blood pressure in adults.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2022Article
- The effect of clinically elevated body mass index on physiological stress during manual lifting activities.PloS one · 2022Article
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Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeObese individuals have reduced performance in cardiopulmonary exercise testing (CPET), mainly considering peak values of variables such as oxygen uptake ([Formula: see text]), carbon dioxide production ([Formula: see text]), tidal volume (Vt), minute ventilation ([Formula: see text]) and heart rate (HR). The CPET interpretation and prognostic value can be improved through submaximal ratios analysis of key variables like [Formula: see text], [Formula: see text], [Formula: see text] [Formula: see text] and oxygen uptake efficiency slope (OUES). The obesity influence on these responses has not yet been investigated. Our purpose was to evaluate the influence of adulthood obesity on maximal and submaximal physiological responses during CPET, emphasizing the analysis of submaximal dynamic variables.
methodsWe analyzed 1,594 CPETs of adults (755 obese participants, Body Mass Index ≥ 30 kg/m2) and compared the obtained variables among non-obese (normal weight and overweight) and obese groups (obesity classes I, II and III) through multivariate covariance analyses.
resultObesity influenced the majority of evaluated maximal and submaximal responses with worsened CPET performance. Cardiovascular, metabolic and gas exchange variables were the most influenced by obesity. Other maximal and submaximal responses were altered only in morbidly obese. Only a few cardiovascular and ventilatory variables presented inconsistent results. Additionally, Vtmax, [Formula: see text], Vt/Inspiratory Capacity, Vt/Forced Vital Capacity, Lowest [Formula: see text], [Formula: see text], and the y-intercepts of [Formula: see text] did not significantly differ regardless of obesity.
conclusionObesity expressively influences the majority of CPET variables. However, the prognostic values of the main ventilatory efficiency responses remain unchanged. These dynamic responses are not dependent on maximum effort and may be useful in detecting incipient ventilatory disorder. Our results present great practical applicability in identifying exercise limitation, regardless of overweight and obesity.
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