Evidence map›Paper›PMID 34370713›Full record

ArticleAging2021

Exosomal lncRNA LINC01711 facilitates metastasis of esophageal squamous cell carcinoma via the miR-326/FSCN1 axis.

Mei-Ling Xu, Tian-Cheng Liu, Feng-Xiang Dong, Ling-Xin Meng, Ai-Xia Ling, Shan Liu

Open access · hybridAbstract read
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. The role of exosomal long non-coding RNAs in head, neck and thyroid cancers.Medical oncology (Northwood, London, England) · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Current issues in molecular biology · 2025
    Article
  9. Exosomes in esophageal cancer: function and therapeutic prospects.Medical oncology (Northwood, London, England) · 2024
    Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mei-Ling XuDepartment of Oncology, Rizhao People's Hospital, Rizhao, Shandong Province, China.
Tian-Cheng LiuFirst Department of Oncology, People's Hospital of Juxian, Rizhao, Shandong Province, China.
Feng-Xiang DongFirst Department of Oncology, People's Hospital of Juxian, Rizhao, Shandong Province, China.
Ling-Xin MengDepartment of Oncology, Rizhao People's Hospital, Rizhao, Shandong Province, China.
Ai-Xia LingDepartment of Physical-Chemistry, College of Pharmaceutical Sciences, Jining Medical College, Jinan, Shandong Province, China.
Shan LiuDepartment of Oncology, Rizhao People's Hospital, Rizhao, Shandong Province, China.
People’s Hospital of Rizhao · CNJining Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Esophageal cancer is a malignant tumor with a five-year survival rate of less than 20%. Early diagnosis and exploration of esophageal cancer pathogenesis are of great significance for the treatment and prognosis of esophageal cancer. Long non-coding RNA (lncRNA) plays a vital role in the occurrence and development of different types of tumors. However, the role of exosome LncRNA in esophageal squamous cell carcinoma (ESCC) is rarely reported. In this study, we detected high expression of lncRNA LINC01711 in ESCC tissues and was associated with poor prognosis. Silencing LINC01711 can inhibit the proliferation, migration, invasion, and growth of ESCC cell lines, and induce apoptosis. Linc01711 was identified as a competitive endogenous RNA that suppressed miR-326, and up-regulated the expression of fascin actin-bundling protein 1 (FSCN1). Besides,

Indexed as

AnimalsApoptosisCarrier ProteinsCell Line, TumorCell MovementCell ProliferationEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaGene Expression Regulation, NeoplasticHeterograftsHumansMiceMice, Inbred BALB CMice, NudeMicrofilament ProteinsMicroRNAsCarrier ProteinsFSCN1 protein, humanMicrofilament ProteinsMicroRNAsMIRN326 microRNA, humanRNA, Long Noncodingesophageal squamous cell carcinomaexosomeLinc01711metastasismiR-326

Identifiers

PMID34370713
PMCPMC8386530
OpenAlexW3189051599

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.