Evidence map›Paper›PMID 34370582›Full record

ArticleAntimicrobial agents and chemotherapy2021

Etest ECVs/ECOFFs for Detection of Resistance in Prevalent and Three Nonprevalent

A Espinel-Ingroff, M Sasso, J Turnidge, M Arendrup, F Botterel, N Bourgeois, B Bouteille, E Canton, S Cassaing, E Dannaoui and 17 more

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Prevalence ofJournal of fungi (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 20 institutions in 10 countries.

A Espinel-IngroffVCU Medical Center, Richmond, Virginia, USA.ORCID 0000-0002-9977-9741
M SassoMIVEGEC, Université, Montpellier, CHU de Nîmes, CNRS, IRD, Montpellier, France.ORCID 0000-0002-6539-8545
J TurnidgeAdelaide Medical School and School of Biological Sciences, University of Adelaide, Adelaide, Australia.ORCID 0000-0003-4240-5578
M ArendrupUnit of Mycology, Department of Microbiological Surveillance and Research, Statens Serum Institutgrid.6203.7, Copenhagen, Denmark.ORCID 0000-0002-4747-0144
F BotterelUnité de Parasitologie-Mycologie, CHU Henri Mondor, APHP, Paris, France.
N BourgeoisMIVEGEC, Université Montpellier, CHU de Montpellier, CNRS, IRD, Montpellier, France.
B BouteilleService de Parasitologie-Mycologie, CHU Limoges, Limoges, France.
E CantonGrupo Infección Grave, Instituto Investigación Sanitaria La Fe, Valencia, Spain.
S CassaingService de Parasitologie-Mycologie, CHU Toulouse, Université Paul Sabatier, Toulouse, France.
E DannaouiLaboratoire de Parasitologie-Mycologie, Département de Microbiologie, Université de Paris, Faculté de Médecine, APHP, Hôpital Européen Georges Pompidou, Paris, France.ORCID 0000-0002-2817-3830
M DehaisLaboratoire de Parasitologie Mycologie, Rouen, France.
L DelhaesService de Parasitologie-Mycologie, CHU Bordeaux, France.
D DupontHospices Civils de Lyongrid.413852.9, Institut des Agents Infectieux, Parasitologie-Mycologie Médicale, Université Lyon 1, Lyon, France.
A FekkarAP-HP, Groupe Hospitalier Pitié-Salpêtrière, Service de Parasitologie-Mycologie, Paris, France.ORCID 0000-0001-9954-075X
J FullerWestern University, Ontario, Canada.
G Garcia-EffronLaboratorio de Micología y Diagnóstico Molecular-CONICET, Cátedra de Parasitología y Micología, Fac. Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.
J GarciaHospital Universitario La Pazgrid.81821.32, Madrid, Spain.
G M GonzalezUniversidad Autónoma de Nuevo León, Monterrey, Mexico.
N P GovenderNational Institute for Communicable Diseases, a Division of the National Health Laboratory Service and Faculty of Health Sciences University of Witwatersrand, Johannesburg, South Africa.ORCID 0000-0001-7869-9462
H GueganUniv Rennes, CHU, Inserm, Irset (Institut de Recherche en Santé, Environnement et Travail)-UMR_S 1085, Rennes, France.
J GuineaServicio de Microbiología Clínica y Enfermedades Infecciosas-VIH, Hospital General Universitario Gregorio Marañon and Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.ORCID 0000-0002-7901-8355
S HouzéUniversité de Paris, UMR 261 MERIT, IRD, Service de Parasitologie, AP-HP, Hôpital Bichat, Paris, France.
C Lass-FlörlInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0002-2946-7785
T PelaezHospital Universitario Central de Asturias, Fundación para la Investigación Biosanitaria del Principado de Asturias, Oviedo, Spain.
A ForastieroServicio de Micologia, Laboratorio de Microbiologia, Hospital Britanico, Buenos Aires, Argentina.
M LacknerInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
R MagoboNational Institute for Communicable Diseases, a Division of the National Health Laboratory Service and Faculty of Health Sciences University of Witwatersrand, Johannesburg, South Africa.
Centre National de la Recherche Scientifique · FRInnsbruck Medical University · ATNational Health Laboratory Service · ZAUniversité Paris Cité · FRCentre Hospitalier Universitaire de Bordeaux · FRCentre Hospitalier Universitaire de Limoges · FRCentre Hospitalier Universitaire Henri-Mondor · FRConsejo Nacional de Investigaciones Científicas y Técnicas · ARHospital Británico de Buenos Aires · ARHospital General Universitario Gregorio Marañón · ESHospital Universitario La Paz · ESInserm · FRInstituto de Investigación Sanitaria del Principado de Asturias · ESInstituto de Investigación Sanitaria La Fe · ESSorbonne Université · FRStatens Serum Institut · DKThe University of Adelaide · AUUniversidad Autónoma de Nuevo León · MXUniversité Claude Bernard Lyon 1 · FRUniversité Toulouse III - Paul Sabatier · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Susceptibility testing is an important tool in the clinical setting; its utility is based on the availability of categorical endpoints, breakpoints (BPs), or epidemiological cutoff values (ECVs/ECOFFs). CLSI and EUCAST have developed antifungal susceptibility testing, BPs, and ECVs for some fungal species. Although the concentration gradient strip bioMérieux Etest is useful for routine testing in the clinical laboratory, ECVs are not available for all agent/species; the lack of clinical data precludes development of BPs. We reevaluated and consolidated Etest data points from three previous studies and included new data. We defined ECOFFinder Etest ECVs for three sets of species-agent combinations: fluconazole, posaconazole, and voriconazole and 9

Indexed as

Amphotericin BCandidaAntifungal AgentsAspergillusCaspofunginDisk Diffusion Antimicrobial TestsDrug Resistance, FungalKluyveromycesMicrobial Sensitivity TestsPichiaSaccharomycetalesTriazolesAmphotericin BAntifungal AgentsCaspofunginTriazolesamphotericin Bantifungal resistanceAspergillus spp.CandidacaspofunginECOFFSECVsERG11 mutantsnonprevalent Candidatriazoles

Identifiers

PMID34370582
PMCPMC8522771
OpenAlexW3191474491

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.