Evidence map›Paper›PMID 34370556›Full record

ArticleJournal of bacteriology2021

SigV Mediates Lysozyme Resistance in Enterococcus faecalis via RsiV and PgdA.

Srivatsan Parthasarathy, Xiaofei Wang, Kristen R Carr, Sriram Varahan, Elyssa B Hancock, Lynn E Hancock

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Identification of candidate nucleomodulins in ESKAPE bacteria -Frontiers in cellular and infection microbiology · 2026
    Article
  2. Insights into ecology, pathogenesis, and biofilm formation ofMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  3. Culture and amplification-free nanopore sequencing for rapid detection of pathogens and antimicrobial resistance genes from urine.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
    Article
  4. Article
  5. Review
  6. Disruption of theJournal of bacteriology · 2022
    Article
  7. Article
  8. Article
  9. Activation of the extracytoplasmic function σ factor σCurrent opinion in microbiology · 2022
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Srivatsan ParthasarathyDepartment of Molecular Biosciences, University of Kansasgrid.266515.3, Lawrence, Kansas, USA.
Xiaofei WangDepartment of Molecular Biosciences, University of Kansasgrid.266515.3, Lawrence, Kansas, USA.
Kristen R CarrDepartment of Molecular Biosciences, University of Kansasgrid.266515.3, Lawrence, Kansas, USA.
Sriram VarahanDepartment of Molecular Biosciences, University of Kansasgrid.266515.3, Lawrence, Kansas, USA.
Elyssa B HancockDepartment of Molecular Biosciences, University of Kansasgrid.266515.3, Lawrence, Kansas, USA.
Lynn E HancockDepartment of Molecular Biosciences, University of Kansasgrid.266515.3, Lawrence, Kansas, USA.ORCID 0000-0003-3372-5406
University of Kansas · US

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Douglas E Wright · 2012 to 2026
$63.0M
Understanding the mechanobiology of stem cells in a microengineered 3D cardiac tissue environment with cardiomyopathyP20GM103638 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI LUNTE, SUSAN M · 2012 to 2021
$22.1M
The regulation of autolysis in Enterococcus faecalisR01AI077782 · NIAID · UNIVERSITY OF KANSAS LAWRENCE · PI HANCOCK, LYNN E · 2010 to 2014
$1.4M
The role of peptide signaling in Enterococcus faecalis biofilm developmentR21AI117424 · NIAID · UNIVERSITY OF KANSAS LAWRENCE · PI HANCOCK, LYNN E · 2017 to 2018
$407k
NIAID NIH HHS AI117424NIAID NIH HHS AI77782NIGMS NIH HHS P20 GM103418NIGMS NIH HHS P20 GM103638
6 · The paper itself

Abstract

Enterococcus faecalis is a gut commensal but transitions to a pathogenic state as a consequence of intestinal dysbiosis and/or the presence of indwelling medical devices, causing a wide range of infections. One of the unique features of E. faecalis is its ability to display high level resistance to lysozyme, an important host defense of the innate immune response. Lysozyme resistance in E. faecalis is known to be mediated by the

Indexed as

MuramidaseCell WallEnterococcus faecalisGene Expression Regulation, BacterialRegulonSigma FactorMuramidaseSigma FactorSigV protein, Enterococcus faecalisEnterococcus faecalislysozymePgdARsiVSigV

Identifiers

PMID34370556
PMCPMC8459761
OpenAlexW3193110995

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.