Evidence map›Paper›PMID 34370507›Full record

ArticleInfection and immunity2021

The Zinc Transporter ZnuABC Is Critical for the Virulence of Chromobacterium violaceum and Contributes to Diverse Zinc-Dependent Physiological Processes.

Renato E R S Santos, Waldir P da Silva Júnior, Simone Harrison, Eric P Skaar, Walter J Chazin, José F da Silva Neto

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. The genes zntA and zntR encoding a P-type ATPase and its activator confer zinc and cadmium resistance in Chromobacterium violaceum.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article
  2. Tylosin Removal Under PbAntioxidants (Basel, Switzerland) · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Cryo-electron microscopy structure of a zinc uptake ABC transporter.bioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Article
  10. Virulence regulation of ZnFrontiers in veterinary science · 2023
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Renato E R S Santos *Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.ORCID 0000-0002-8702-4202
Waldir P da Silva Júnior *Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
Simone HarrisonDepartment of Biochemistry, Vanderbilt Universitygrid.152326.1, Nashville, Tennessee, USA.
Eric P SkaarDepartment of Pathology, Microbiology, and Immunology, Vanderbilt Universitygrid.152326.1 Medical Center, Nashville, Tennessee, USA.
Walter J ChazinDepartment of Biochemistry, Vanderbilt Universitygrid.152326.1, Nashville, Tennessee, USA.
José F da Silva NetoDepartamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.ORCID 0000-0002-7946-2747
Universidade de São Paulo · BRVanderbilt University · USVanderbilt University Medical Center · US

Funding

Host-mediated zinc sequestration during Acinetobacter baumannii infectionR01AI101171 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WALTER J. CHAZIN, DAVID P. GIEDROC · 2013 to 2026
$8.2M
Chemical Biology of Infectious Diseases (CBID) Training ProgramT32AI112541 · NIAID · VANDERBILT UNIVERSITY · PI Eric P Skaar · 2015 to 2026
$4.0M
The Staphylococcus aureus response to nutrient zinc restriction during infectionR01AI150701 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SKAAR, ERIC P · 2020 to 2024
$2.1M
HHS | National Institutes of Health (NIH) R01 RAI150701NIAID NIH HHS R01 AI101171NIAID NIH HHS R01 AI150701NIAID NIH HHS T32 AI112541
6 · The paper itself

Abstract

Chromobacterium violaceum is a ubiquitous environmental bacterium that causes sporadic life-threatening infections in humans. How C. violaceum acquires zinc to colonize environmental and host niches is unknown. In this work, we demonstrated that C. violaceum employs the zinc uptake system ZnuABC to overcome zinc limitation in the host, ensuring the zinc supply for several physiological demands. Our data indicated that the C. violaceum ZnuABC transporter is encoded in a

Indexed as

BiofilmsCarrier ProteinsChromobacteriumLeukocyte L1 Antigen ComplexNeutrophilsOperonVirulenceZincCarrier ProteinsLeukocyte L1 Antigen ComplexZinczinc-binding proteinbacterial virulencebacterial zinc transportercalprotectinChromobacterium violaceummetalloregulatorzinc homeostasiszinc uptake regulatorZnuABC

Identifiers

PMID34370507
PMCPMC8519291
OpenAlexW3190628424

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.