Evidence map›Paper›PMID 34370398›Full record

ArticleCurrent protocols2021

Evaluating Gait and Locomotion in Rodents with the CatWalk.

Jacqueline M Garrick, Lucio G Costa, Toby B Cole, Judit Marsillach

Open access · greenAbstract read
In one paragraph

Article in Current protocols, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 45 citations in OpenAlex.

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  6. The influence of trait anxiety on performance in the CatWalk test.Frontiers in behavioral neuroscience · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Jacqueline M GarrickDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington.
Lucio G CostaDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington.
Toby B ColeDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington.
Judit MarsillachDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington.
University of Washington · USInstitute of Translational Health Sciences · USUniversity of Parma · IT

Funding

WILDLIFE BIOMARKER APPLICATIONS TO REMEDIATION DECISION MAKINGP42ES004696 · NIEHS · UNIVERSITY OF WASHINGTON · PI FURLONG, CLEMENT EUGENE · 1987 to 2021
$51.2M
XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Sheela Sathyanarayana · 1995 to 2026
$42.5M
Mechanisms of Brain Dysmorphology in MN1 C-Terminal Truncation Syndrome, a Novel Intellectual Developmental Disability Disorder P50HD103524 · NICHD · UNIVERSITY OF WASHINGTON · PI Sandra E Juul · 2020 to 2026
$9.9M
Gene-environment interactions in the developmental neurotoxicity of air pollutionR01ES028273 · NIEHS · UNIVERSITY OF WASHINGTON · PI COSTA, LUCIO G · 2017 to 2021
$2.0M
NICHD NIH HHS P50 HD103524NIEHS NIH HHS P30 ES007033NIEHS NIH HHS P42 ES004696NIEHS NIH HHS R01 ES028273NIH HHS P42ES04696NIH HHS R01ES028273
6 · The paper itself

Abstract

Motor deficits can significantly affect the completion of daily life activities and have a negative impact on quality of life. Consequently, motor function is an important behavioral endpoint to measure for in vivo pathophysiologic studies in a variety of research areas, such as toxicant exposure, drug development, disease characterization, and transgenic phenotyping. Evaluation of motor function is also critical to the interpretation of cognitive behavioral assays, as many rely on intact motor abilities to derive meaningful data. As such, gait analysis is an important component of behavioral research and can be achieved by manual or video-assisted methods. Manual gait analysis methods, however, are prone to observer bias and are unable to capture many critical parameters. In contrast, automated video-assisted gait analysis can quickly and reliably assess gait and locomotor abnormalities that were previously difficult to collect manually. Here, we describe the evaluation of gait and locomotion in rodents using the automated Noldus CatWalk XT system. We include a step-by-step guide for running an experiment using the CatWalk XT system and discuss theory and considerations when evaluating rodent gait. The protocol and discussion provided here act as a supplemental resource to the manual for this commercially available system and can assist CatWalk users in their experimental design and implementation. © 2021 Wiley Periodicals LLC.

Indexed as

Quality of LifeRodentiaAnimalsGaitGait AnalysisLocomotionCatWalkgaitlocomotionmotor deficitsphenotypingrodents

Identifiers

PMID34370398
PMCPMC8363132
OpenAlexW3192810265

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.