Evidence map›Paper›PMID 34370313›Full record

ArticleAnnals of neurology2021

Leucine-Rich Glioma-Inactivated 1 versus Contactin-Associated Protein-like 2 Antibody Neuropathic Pain: Clinical and Biological Comparisons.

Sudarshini Ramanathan, Mandy Tseng, Alexander J Davies, Christopher E Uy, Sofija Paneva, Victor C Mgbachi, Sophia Michael, James A Varley, Sophie Binks, Andreas C Themistocleous and 11 more

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 56 citations in OpenAlex.

  1. Review
  2. Recent advances in autoantibody-mediated pain.Current opinion in supportive and palliative care · 2026
    Review
  3. Review
  4. Review
  5. Autoantibodies as drivers of neuropathic pain.Trends in molecular medicine · 2026
    Review
  6. Review
  7. High Relapse Rate in Anti-CASPR2 Disease: Implications for Prolonged Immunotherapy.Neurology(R) neuroimmunology & neuroinflammation · 2026
    Observational
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Characterizing Acute-Onset Small Fiber Neuropathy.Neurology(R) neuroimmunology & neuroinflammation · 2024
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 3 countries.

Sudarshini RamanathanOxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.ORCID 0000-0002-0294-9768
Mandy TsengNeural Injury Group, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Alexander J DaviesInflammatory Neuropathy Group, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.ORCID 0000-0003-0072-1708
Christopher E UyOxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Sofija PanevaOxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Victor C MgbachiOxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Sophia MichaelOxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
James A VarleyOxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Sophie BinksOxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Andreas C ThemistocleousNeural Injury Group, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.ORCID 0000-0002-1089-1543
Janev FehmiInflammatory Neuropathy Group, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Yaacov AnziskaOxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Anushka SoniWellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Monika HoferDepartment of Neuropathology, Oxford University Hospital, National Health Service Foundation Trust, Oxford, UK.
Patrick WatersOxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Fabienne BrilotNeuroimmunology and Brain Autoimmunity Groups, Kids Neuroscience Centre, Children's Hospital at Westmead; Brain and Mind Centre and Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Russell C DaleNeuroimmunology and Brain Autoimmunity Groups, Kids Neuroscience Centre, Children's Hospital at Westmead; Brain and Mind Centre and Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
John DawesNeural Injury Group, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Simon RinaldiInflammatory Neuropathy Group, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.ORCID 0000-0003-2039-3457
David L Bennett *Neural Injury Group, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Sarosh R Irani *Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.ORCID 0000-0002-7667-9748
John Radcliffe Hospital · GBThe University of Sydney · AUNational Health Service · GBUniversity of British Columbia · CA

Funding

British Medical Association Vera Down grant (2013) and Margaret Temple (2017)Epilepsy Research UK P1201Medical Research Council MR/M02394X/1Medical Research Council MR/V003534/1Medical Research Council MR/V007173/1Wellcome TrustWellcome Trust 104079/Z/14/Z
6 · The paper itself

Abstract

Pain is a under-recognized association of leucine-rich glioma-inactivated 1 (LGI1) and contactin-associated protein-like 2 (CASPR2) antibodies. Of 147 patients with these autoantibodies, pain was experienced by 17 of 33 (52%) with CASPR2- versus 20 of 108 (19%) with LGI1 antibodies (p = 0.0005), and identified as neuropathic in 89% versus 58% of these, respectively. Typically, in both cohorts, normal nerve conduction studies and reduced intraepidermal nerve fiber densities were observed in the sampled patient subsets. In LGI1 antibody patients, pain responded to immunotherapy (p = 0.008), often rapidly, with greater residual patient-rated impairment observed in CASPR2 antibody patients (p = 0.019). Serum CASPR2 antibodies, but not LGI1 antibodies, bound in vitro to unmyelinated human sensory neurons and rodent dorsal root ganglia, suggesting pathophysiological differences that may underlie our clinical observations. ANN NEUROL 2021;90:683-690.

Indexed as

AutoantibodiesCell Adhesion Molecules, NeuronalHumansIntracellular Signaling Peptides and ProteinsMembrane ProteinsNerve Tissue ProteinsNeuralgiaPotassium Channels, Voltage-Gatedanti-leucine-rich glioma-inactivated 1 autoantibodyAutoantibodiesCell Adhesion Molecules, NeuronalCNTNAP1 protein, humanCNTNAP2 protein, humanIntracellular Signaling Peptides and ProteinsMembrane ProteinsNerve Tissue ProteinsPotassium Channels, Voltage-Gated

Identifiers

PMID34370313
PMCPMC8581990
OpenAlexW3190148184

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.