Evidence map›Paper›PMID 34370210›Full record

ArticleJournal of assisted reproduction and genetics2021

Predictive factors for fertility preservation in pediatric and adolescent girls with planned gonadotoxic treatment.

Glory E Mgboji, Christina N Cordeiro Mitchell, Bronwyn S Bedrick, Dhananjay Vaidya, Xueting Tao, Yisi Liu, Jacqueline Y Maher, Mindy S Christianson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Glory E MgbojiDepartment of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. gmgboji1@jhmi.edu.ORCID http://orcid.org/0000-0003-2493-0838
Christina N Cordeiro MitchellDepartment of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-0402-2536
Bronwyn S BedrickDepartment of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-1933-5586
Dhananjay VaidyaDepartment of Internal Medicine/Biostatistics, Epidemiology, and Data Management, Johns Hopkins University School of Medicine/Bloomberg School of Public Health, Baltimore, MD, USA.
Xueting TaoDepartment of Biostatistics, Epidemiology, and Data Management, Johns Hopkins University School of Medicine/Bloomberg School of Public Health, Baltimore, MD, USA.
Yisi LiuDepartment of Biostatistics, Epidemiology, and Data Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Jacqueline Y MaherDepartment of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mindy S ChristiansonDepartment of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0001-6749-2773
Johns Hopkins University · USBio-Rad (United States) · USChildren's National · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo characterize female pediatric and adolescent patients seen for fertility preservation consultation at an academic medical center and to describe the association between demographic or clinical factors and the use of fertility preservation treatment (FPT).

methodsThis is a retrospective chart analysis of female pediatric and adolescent patients seen for fertility preservation consultation at an academic fertility center over a 14-year period from 2005 to 2019.

resultsOne hundred six females aged 3-21 years were seen for fertility preservation consultation with a mean age of 16.6 years. Diagnoses included hematologic malignancies (41.5%), gynecologic malignancies (9.4%), other malignancies (31.1%), non-malignant hematologic disease (14.2%), and non-malignant conditions (3.8%). Overall, 64.2% of subjects pursued fertility preservation, including oocyte cryopreservation (35.8%) and ovarian tissue cryopreservation (23.6%). Overall, age, minority race, diagnosis, time since diagnosis, and median household income were not significantly associated with odds of completing an FPT procedure. Among all patients, those who underwent gonadotoxic therapy prior to consultation had a lower odds of receiving FPT (OR= 0.24, 95% CI 0.10-0.55). Among patients without chemotherapy exposure, no factors were associated with FPT.

conclusionsAmong pediatric and adolescent patients at an academic center undergoing a fertility preservation consultation, there were no socioeconomic or clinical barriers to FPT use in those who had not yet undergone gonadotoxic therapy. The only factor that was negatively associated with odds of pursuing FPT was prior chemotherapy exposure.

Indexed as

AdolescentAdultAntineoplastic AgentsChildChild, PreschoolFemaleFertility Agents, FemaleFertility PreservationHumansInfertility, FemaleNeoplasmsOvaryRetrospective StudiesYoung AdultAntineoplastic AgentsFertility Agents, FemaleGonadotoxic treatmentOvarian tissue cryopreservationPediatric fertility preservation

Identifiers

PMID34370210
PMCPMC8581078
OpenAlexW3192070522

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.