Evidence map›Paper›PMID 34370174›Full record

ReviewInternational ophthalmology2022

Ocular toxoplasmosis: a review of the current diagnostic and therapeutic approaches.

Dimitrios Kalogeropoulos, Hercules Sakkas, Bashar Mohammed, Georgios Vartholomatos, Konstantinos Malamos, Sreekanth Sreekantam, Panagiotis Kanavaros, Chris Kalogeropoulos

Abstract readReview
In one paragraph

Review in International ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  19. Intraocular Coinfection byPathogens (Basel, Switzerland) · 2025
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dimitrios KalogeropoulosDepartment of Ophthalmology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Stavros Niarchos Ave, 45500, Ioannina, Greece. dkalog1990@gmail.com.ORCID http://orcid.org/0000-0001-6404-5409
Hercules SakkasMicrobiology Department, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.
Bashar MohammedBirmingham and Midland Eye Centre, Birmingham, UK.
Georgios VartholomatosHematology Laboratory, Unit of Molecular Biology, University Hospital of Ioannina, Ioannina, Greece.
Konstantinos MalamosDepartment of Ophthalmology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Stavros Niarchos Ave, 45500, Ioannina, Greece.
Sreekanth SreekantamBirmingham and Midland Eye Centre, Birmingham, UK.
Panagiotis KanavarosDepartment of Anatomy-Histology-Embryology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.
Chris KalogeropoulosDepartment of Ophthalmology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Stavros Niarchos Ave, 45500, Ioannina, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis review aims to summarize the current knowledge concerning the clinical features, diagnostic work-up and therapeutic approach of ocular toxoplasmosis focusing mainly on the postnatally acquired form of the disease.

methodsA meticulous literature search was performed in the PubMed database. A supplementary search was made in Google Scholar to complete the collected items.

resultsOcular toxoplasmosis is one of the most frequent infectious etiologies of posterior uveitis. It typically presents with retinochoroiditis. Setting an accurate diagnosis depends to a considerable degree on detecting characteristic clinical characteristics. In addition to the evaluation of clinical features, the diagnosis of toxoplasmosis relies at a large degree on serologic testing. The detection of the parasite DNA in the aqueous or vitreous humor can provide evidence for a definitive diagnosis. The current mainstay for the treatment, if necessary, is the use of oral antibiotic with systemic corticosteroids. Recent evidence suggests other therapeutic approaches, such as intravitreal antibiotics can be used.

conclusionRecent developments in the diagnostic and therapeutic approach have contributed to preventing or limiting vision loss of patients suffering from ocular toxoplasmosis. Further studies are required to provide a better understanding of epidemiology, pathogenesis, diagnosis, and treatment with a significant impact on the management of this challenging clinical entity.

Indexed as

ChorioretinitisToxoplasmaToxoplasmosis, OcularUveitis, PosteriorEyeHumansOcular toxoplasmosisPosterior uveitisRetinochoroiditisToxoplasma gondii

Identifiers

PMID34370174
PMCPMC8351587

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.