ArticleEuropean journal of epidemiology2021
Association between body mass index, its change and cognitive impairment among Chinese older adults: a community-based, 9-year prospective cohort study.
Article in European journal of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Independent and Combined Effects of Obesity and Cardiovascular Diseases on the Risk of Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis of Prospective Cohort Studies Involving 8,276,914 Participants.International journal of molecular sciences · 2026Pooled it
- The relationship between changes in body weight and cognitive function in the elderly.International journal of obesity (2005) · 2026Article
- Association between herpes zoster and cognitive impairment among Chinese community-dwelling elderly: a cross-sectional study.BMC public health · 2026Observational
- Parental age and its influence on functional dependency and cognitive decline in older adults: a cohort analysis.Journal of health, population, and nutrition · 2026Article
- Menstrual and reproductive factors and risk of Alzheimer's disease in elderly women: a cohort study in Eastern China.Scientific reports · 2026Article
- Excessive sleep duration increases the risk of dementia among older Chinese adults: evidence from the CLHLS.BMC geriatrics · 2026Article
- Cognitive function in normotensive elderly adults: a population-based cross-sectional study in rural China.Frontiers in medicine · 2026Article
- Observational
- Article
- Association between cognitive impairment and comprehensive weight phenotypes among older adults in China: a nationwide survey.Aging clinical and experimental research · 2025Article
- Body mass index trajectories in older adulthood and all-cause mortality: a cohort study in China.BMC public health · 2025Article
- Association between dietary patterns and existing natural teeth in Chinese elderly: a national community-based study.Frontiers in nutrition · 2025Article
- U-shaped association between BMI and cognitive impairment in middle-aged and older adults with type 2 diabetes: effect modification by lifestyle and exercise.Frontiers in public health · 2025Observational
- Relationship between Body Roundness Index and cognitive impairment in middle-aged and older adults: a population-based cross-sectional study.Frontiers in aging neuroscience · 2025Article
- Sensory impairments associated with cognitive impairment among older adults in China: A community-based, 10-year prospective cohort study.Journal of global health · 2024Article
- Relationship between socioeconomic status and hypertension incidence among adults in southwest China: a population-based cohort study.BMC public health · 2024Article
- Association of body mass index with rapid eye movement sleep behavior disorder in Parkinson's disease.Frontiers in neurology · 2024Article
- Investigating causality and shared genetic architecture between body mass index and cognitive function: a genome-wide cross-trait analysis and bi-directional Mendelian randomization study.Frontiers in aging neuroscience · 2024Article
- Association between BMI trajectories in late-middle age and subsequent dementia risk in older age: a 26-year population-based cohort study.BMC geriatrics · 2023Article
- Executive Attentional Dyscontrol as a Core Cognitive and Behavioral Feature of Individuals with Obesity and Cardiovascular Disease: A Cross-Sectional Investigation.Brain sciences · 2023Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
To examine the association of baseline body mass index (BMI) and BMI change with cognitive impairment among older adults in China. The study included data from the Chinese Longitudinal Healthy Longevity Study, a national community-based prospective cohort study from 2002 to 2018. Baseline BMI and BMI change were available for 12,027 adults aged older than 65 years. Cognitive impairment was defined as Chinese version of the Mini Mental State Examination score lower than 18. Multivariable Cox proportional hazard model was used. Among 12,027 participants (mean age was 81.23 years old and 47.48% were male), the proportion of underweight, normal, overweight and obese at baseline was 33.87%, 51.39%, 11.39% and 3.34%, respectively. During an average of 5.9 years' follow-up, 3086 participants (4.35 per 100 person-years) with incident cognitive impairment were identified. Compared with normal weight group, adjusted hazard ratio (AHR) for cognitive impairment was 0.86 (95% CI 0.75-0.99) among overweight group, whereas corresponding AHR was 1.02 (95% CI 0.94-1.10) in underweight and 1.01 (95% CI 0.80-1.28) in obese participants. Large weight loss (< -10%) was significantly associated with an increased risk of cognitive impairment (AHR, 1.42, 95% CI 1.29-1.56), compared to stable weight status group (-5% ~ 5%). In the restricted cubic spline models, BMI change showed a reverse J-shaped association with cognitive impairment. BMI-defined overweight, but not obesity, was associated with a lower risk of cognitive impairment among elderly Chinese adults, while large weight loss was associated with an increased risk. These findings are consistent with weight loss in the prodromal phase of dementia.
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