ArticleAnnals of intensive care2021
P/FP ratio: incorporation of PEEP into the PaO
Article in Annals of intensive care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03946150 (PaO2/FiO2*PEEP), which is not on this map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PaO2/FiO2*PEEP (P/FP) Ratio and Mortality in Acute Respiratory Distress Syndrome
Who cites it
33 citing papers in PubMed.
- Beyond Acute Kidney Injury : Direct Pathways Implicate Inflammatory Mechanisms in Serum NGAL's Mortality Effect in Acute Brain Injury.Translational stroke research · 2026Article
- Mechanical ventilation in ARDS: navigating the fine line with real-time monitoring.Critical care (London, England) · 2026Review
- Anti-inflammatory and antioxidant effects of dipotassium glycyrrhizinate in acute respiratory distress syndrome.Frontiers in medicine · 2026Article
- Article
- Optimal Cutoffs for the Ratio of Arterial Oxygen Partial Pressure to Inspired Oxygen Fraction in Categorizing Respiratory Impairment Severity in Organ Failure Scores.Acta anaesthesiologica Scandinavica · 2026Article
- Prognostic value of disease severity and mechanical ventilation intensity in acute respiratory distress syndrome: analysis of the LUNG SAFE cohort.The European respiratory journal · 2026Observational
- Beyond the PaOAnnals of intensive care · 2026Review
- Intelligent Patient Management in Viral Diseases: An Integrated Regression Model and Multi-Criteria Decision-Making Approach to Convalescent Plasma Transfusion.Healthcare (Basel, Switzerland) · 2025Article
- The Development of a Prediction Model for In-Hospital Mortality of Pneumocystis Jirovecii Pneumonia among Kidney Transplant Recipients Based on the Trajectory of Absolute Lymphocyte Count.Mycopathologia · 2025Article
- Acute Respiratory Distress Syndrome Definitions in Adults and Children: A Comparative Narrative Review.Journal of clinical medicine · 2025Review
- Switching from controlled to assisted mechanical ventilation: a multi-center retrospective study (SWITCH).Intensive care medicine experimental · 2025Article
- Deciphering Oxygenation Metrics in ARDS: A Deep Dive into the OXIVA-CARDS Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- Metabolic Regulation in Acute Respiratory Distress Syndrome: Implications for Inflammation and Oxidative Stress.International journal of chronic obstructive pulmonary disease · 2025Review
- Clinical Characteristics and Mortality Risk Factors in Patients with Tuberculosis and CoincidentInfection and drug resistance · 2025Article
- Oxygenation Index, Oxygen Saturation Index vs PaOIndian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- Oxygenation Indices in Adult COVID ARDS Patients.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- Novel Oxygenation and Saturation Indices for Mortality Prediction in COVID-19 ARDS Patients: The Impact of Driving Pressure and Mechanical Power.Journal of intensive care medicine · 2024Article
- "PEEP-adjusted P/F Ratio" in Acute Respiratory Distress Syndrome: A Call for Further Enhancement of Global Definition.American journal of respiratory and critical care medicine · 2024Article
- Changes in Driving Pressure vs Oxygenation as Predictor of Mortality in Moderate to Severe Acute Respiratory Distress Syndrome Patients Receiving Prone Position Ventilation.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- Association between (ΔPaO2/FiO2)/PEEP and in-hospital mortality in patients with COVID-19 pneumonia: A secondary analysis.PloS one · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe current Berlin definition of acute respiratory distress syndrome (ARDS) uses the PaO
objectivesWe designed a new formula, the P/FP ratio, incorporating PEEP into the P/F ratio and multiplying with a correction factor of 10 [(PaO
methodsWe categorized patients from a dataset of seven ARDS network trials using the thresholds of ≤ 100 (severe), 101-200 (moderate), and 201-300 (mild) for both P/F (mmHg) and P/FP (mmHg/cmH
resultsOut of 3,442 patients, 1,057 (30.7%) died. The AUC for mortality was higher for the P/FP ratio than the P/F ratio for PEEP levels > 5 cmH
conclusionsThe multifactorial P/FP ratio has a greater predictive validity for hospital mortality in ARDS than the P/F ratio. Changes in severity classification with the P/FP ratio reflect both true illness severity and the applied PEEP strategy.
trial registrationClinialTrials.gov-NCT03946150.
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