Evidence map›Paper›PMID 34370102›Full record

ArticleNanoscale research letters2021

The Role of Apoptosis Pathway in the Cytotoxicity Induced by Fresh and Aged Zinc Oxide Nanoparticles.

Juan Wang, Lei Wang, Wenting Zhao, Na Yu, Meiling Cheng, Mingqin Su, Jian Hu, Xiaoyan Wu, Hua Du, Meimei Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanoscale research letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Anticancer Activity of Green Synthesized ZnO Nanoparticles fromNanomaterials (Basel, Switzerland) · 2026
    Article
  2. Gold Nanoparticles Reduce Food Sensation inInternational journal of nanomedicine · 2023
    Article
  3. Sirtuins and Hypoxia in EMT Control.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Juan Wang *Department of Pathophysiology, School of Basic Medical Science, Anhui Medical University, No. 81, Mei-Shan Road, Hefei, 230032, Anhui, People's Republic of China.
Lei Wang *Department of Physiology and Biophysics, Miller School of Medicine, University of Miami, Miami, FL, USA.
Wenting ZhaoDepartment of Pathophysiology, School of Basic Medical Science, Anhui Medical University, No. 81, Mei-Shan Road, Hefei, 230032, Anhui, People's Republic of China.
Na YuDepartment of Pathophysiology, School of Basic Medical Science, Anhui Medical University, No. 81, Mei-Shan Road, Hefei, 230032, Anhui, People's Republic of China.
Meiling ChengDepartment of Pathophysiology, School of Basic Medical Science, Anhui Medical University, No. 81, Mei-Shan Road, Hefei, 230032, Anhui, People's Republic of China.
Mingqin SuDepartment of Pathophysiology, School of Basic Medical Science, Anhui Medical University, No. 81, Mei-Shan Road, Hefei, 230032, Anhui, People's Republic of China.
Jian HuDepartment of Pathophysiology, School of Basic Medical Science, Anhui Medical University, No. 81, Mei-Shan Road, Hefei, 230032, Anhui, People's Republic of China.
Xiaoyan WuMOE Key Laboratory of Population Health Across Life Cycle, No. 81, Mei-Shan Road, Hefei, 230032, Anhui, People's Republic of China.
Hua DuHigh Magnetic Field Laboratory, Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, People's Republic of China. huadu@ipp.ac.cn.
Meimei WangDepartment of Pathophysiology, School of Basic Medical Science, Anhui Medical University, No. 81, Mei-Shan Road, Hefei, 230032, Anhui, People's Republic of China. wangmm@ustc.edu.cn.ORCID http://orcid.org/0000-0002-2671-9748
Anhui Medical University · CNChinese Academy of Sciences · CNUniversity of Miami · USUniversity of Science and Technology of China · CN

Funding

Anhui Provincial Natural Science Foundation 2008085MB49"Hundred Talents Program" of the Chinese Academy of Sciences E09BR22National Natural Science Foundation of China 21507002National Natural Science Foundation of China 21677147National Natural Science Foundation of China 22006149National undergraduate innovation and entrepreneurship training program 202010366043Open project fund of the key laboratory of the ministry of education for the birth population JKZD20202
6 · The paper itself

Abstract

Zinc oxide nanoparticles (ZnO NPs) are used in a wide range of applications including industry, commercial products and medicine field. Numerous mechanistic studies for ZnO NPs' toxicity were performed on pristine (fresh) NPs. However, the cytotoxicity induced by the transformed (aged) ZnO NPs and the underlying mechanisms remain unclear. Here, we observed the physicochemical transformation of ZnO NPs underwent over time, followed by evaluating the cytotoxicity of fresh and aged NPs. We found that fresh ZnO NPs induced higher apoptosis level than their aged counterparts. Accordingly, RNA sequencing data from aged ZnO NP-treated human-hamster hybrid (A

Indexed as

Aged zinc oxide nanoparticlesApoptosisCytotoxicityMechanismTranscriptomics

Identifiers

PMID34370102
PMCPMC8353024
OpenAlexW3192948228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.