Evidence map›Paper›PMID 34370099›Full record

ArticleClinical oral investigations2022

Influence of selective immunosuppressive drug regimens on the healing of exposed dogs' dental pulp capped with a recent calcium silicate-based cement.

Hanan A Soliman, Radwa Ibrahim El-Toukhy, Mona Mohsen Ebrahim, Mohammed E Grawish, Mohamed Abdel Kader Sobh, Salah Hasab Mahmoud

Abstract read
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Article in Clinical oral investigations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hanan A SolimanOperative Dentistry Department, Faculty of Dentistry, Kafrelsheikh University, Kafr El Sheikh, Egypt.
Radwa Ibrahim El-ToukhyOperative Dentistry Department, Faculty of Dentistry, Mansoura University, 77 Al Gomhoria St, Mansoura, 35516, Egypt.
Mona Mohsen EbrahimOral Pathology Department, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.
Mohammed E GrawishOral Biology Department, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.
Mohamed Abdel Kader SobhNephrology Department, Urology and Nephrology Center, Faculty of Medicine, Mansoura, Egypt.
Salah Hasab MahmoudOperative Dentistry Department, Faculty of Dentistry, Mansoura University, 77 Al Gomhoria St, Mansoura, 35516, Egypt. salahmahmoud2010@yahoo.com.ORCID http://orcid.org/0000-0002-5243-3209
Mansoura University · EGKafrelsheikh University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesIn the clinical medicine, immunosuppressive drugs are used for an assortment of disorders, while their effect on the pulp healing is a controversial issue. This study evaluated the effect of different immunosuppressive drugs on the healing capacity of mechanically exposed dogs' dental pulps after direct pulp capping (DPC) with calcium silicate-based cement. MATERIALS AND

methodsTwelve healthy male dogs were randomly allocated into four equal groups, 3 dogs each: group I allocated as a control group where no drugs were received; group П given prednisone (Pred); group III given a combination of Pred and cyclosporine A (CsA); and group IV given triple dose including Pred, CsA, and mycophenolate mofetil (MMF) for 45 days before the operative procedures and until the dogs were euthanized. In each dog, 16 class V cavities were prepared on the labial surfaces of anterior teeth. Following mechanical exposure, the pulps were capped with Biodentine, calcium silicate-based cement. The pulpal tissues response to Biodentine was assessed 65 days postoperatively.

resultsThe pulp healing response was inferior in the Pred-CsA- and Pred-CsA-MMF-treated groups compared with the control and Pred-treated groups (P < 0.05). Non-significant difference was found between control and Pred-treated groups (P > 0.05).

conclusionsWithin the limitation of this study, DPC with calcium silicate-based cement performed under strict aseptic condition for traumatically exposed dental pulp can be considered as a successful treatment option for those who receiving Pred immunosuppressive therapy. Meanwhile, DPC with those receiving a combination of Pred, CsA, and/or MMF immunosuppressive drug regimens demonstrated unfavorable results. CLINICAL RELEVANCE: Direct capping of mechanically exposed pulps with calcium silicate-based cement performed with special care for preventing infection considered a suitable strategic measure for preserving pulp vitality in patients receiving corticosteroid immunosuppressive drug.

Indexed as

Pharmaceutical PreparationsSilicate CementAnimalsCalciumCalcium CompoundsCalcium HydroxideDental PulpDental Pulp CappingDental Pulp ExposureDogsHumansMaleOxidesSilicatesCalciumCalcium CompoundsCalcium Hydroxidecalcium silicateOxidesPharmaceutical PreparationsSilicate CementSilicatesDirect pulp capping techniqueDogs’ teethImmunosuppressive drugsPulp capping materials

Identifiers

PMID34370099
OpenAlexW3190690034

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.