Evidence map›Paper›PMID 34370077›Full record

ReviewArchives of microbiology2021

Therapeutic applications and biological activities of bacterial bioactive extracts.

Zainab Abdelghani, Nancy Hourani, Zahraa Zaidan, Ghassan Dbaibo, Marguerite Mrad, Rouba Hage-Sleiman

Abstract readReview
In one paragraph

Review in Archives of microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Promising Prodiginins Biological Activities.Chemistry & biodiversity · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. International journal of molecular sciences · 2024
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. RSC advances · 2023
    Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zainab AbdelghaniDepartment of Biology, Faculty of Sciences, Lebanese University, Hadath, Lebanon.
Nancy HouraniDepartment of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.ORCID http://orcid.org/0000-0002-0597-0044
Zahraa ZaidanDepartment of Biology, Faculty of Sciences, Lebanese University, Hadath, Lebanon.
Ghassan DbaiboDepartment of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Marguerite MradDepartment of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon. mm220@aub.edu.lb.
Rouba Hage-SleimanDepartment of Biology, Faculty of Sciences, Lebanese University, Hadath, Lebanon. rouba.hagesleiman@ul.edu.lb.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacteria are rich in a wide variety of secondary metabolites, such as pigments, alkaloids, antibiotics, and others. These bioactive microbial products serve a great application in human and animal health. Their molecular diversity allows these natural products to possess several therapeutic attributes and biological functions. That's why the current natural drug industry focuses on uncovering all the possible ailments and diseases that could be combated by bacterial extracts and their secondary metabolites. In this paper, we review the major utilizations of bacterial natural products for the treatment of cancer, inflammatory diseases, allergies, autoimmune diseases, infections and other diseases that threaten public health. We also elaborate on the identified biological activities of bacterial secondary metabolites including antibacterial, antifungal, antiviral and antioxidant activities all of which are essential nowadays with the emergence of drug-resistant microbial pathogens. Throughout this review, we discuss the possible mechanisms of actions in which bacterial-derived biologically active molecular entities could possess healing properties to inspire the development of new therapeutic agents in academia and industry.

Indexed as

Anti-Infective AgentsBiological ProductsAnimalsAnti-Bacterial AgentsAntifungal AgentsBacteriaHumansAnti-Bacterial AgentsAntifungal AgentsAnti-Infective AgentsBiological ProductsAntibacterialAnti-cancerAntifungalAntioxidantAntiviralBacterial extractsImmunomodulationSecondary metabolites

Identifiers

PMID34370077
PMCPMC8349711

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.