Evidence map›Paper›PMID 34369878›Full record

ArticleeLife2021

Variation in the modality of a yeast signaling pathway is mediated by a single regulator.

Julius Palme, Jue Wang, Michael Springer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Identification of RNA-Binding Protein Targets with HyperTRIBE inInternational journal of molecular sciences · 2023
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Julius Palme *Department of Systems Biology, Harvard Medical School, Boston, United States.ORCID 0000-0001-5897-1334
Jue Wang *Department of Chemical Engineering, University of Washington, Seattle, United States.
Michael SpringerDepartment of Systems Biology, Harvard Medical School, Boston, United States.ORCID 0000-0002-3970-6380
Harvard University · USUniversity of Washington · US

Funding

Determining the source of missing heritabilityR01GM120122 · NIGMS · HARVARD MEDICAL SCHOOL · PI SPRINGER, MICHAEL · 2016 to 2020
$1.7M
NIGMS NIH HHS R01 GM120122
6 · The paper itself

Abstract

Bimodal gene expression by genetically identical cells is a pervasive feature of signaling networks and has been suggested to allow organisms to hedge their 'bets' in uncertain conditions. In the galactose-utilization (GAL) pathway of

Indexed as

Gene Expression Regulation, FungalGenetic VariationGalactoseGenetic FitnessSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSignal TransductionTranscription FactorsGal3 protein, S cerevisiaeGalactoseSaccharomyces cerevisiae ProteinsTranscription Factorscomputational biologygene regulationnutrient signalingphenotypic variationS. cerevisiaesystems biology

Identifiers

PMID34369878
PMCPMC8373380
OpenAlexW3188964407

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.