ArticleMedical physics2021
The impact of MR-based attenuation correction in spinal cord FDG-PET/MR imaging for neurological studies.
Article in Medical physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- [ 18 F]fluorodeoxyglucose PET/MRI for nononcological musculoskeletal indications: reference uptake values in the asymptomatic lumbar spine and example comparison to a low back pain patient.Nuclear medicine communications · 2026Article
- MRI-Based Machine Learning and Radiomics Methods for Assessing Spinal Cord Function in Patients with Mild Cervical Spondylotic Myelopathy.Bioengineering (Basel, Switzerland) · 2025Article
- Quantification of FDG in the spinal cord using PET/MRI.Frontiers in nuclear medicine · 2025Article
- The pons as an optimal background reference region for spinalEJNMMI research · 2024Article
- The impact of MR-based attenuation correction in spinal cord FDG-PET/MR imaging for neurological studies.Medical physics · 2021Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePositron emission tomography (PET) attenuation correction (AC) in positron emission tomography-magnetic resonance (PET/MR) scanners constitutes a critical and barely explored issue in spinal cord investigation, mainly due to the limitations in accounting for highly attenuating bone structures which surround the spinal canal. Our study aims at evaluating the clinical suitability of MR-driven AC (MRAC) for 18-fluorodeoxy-glucose positron emission tomography (
methodsThirty-six patients, undergoing positron emission tomography-computed tomography (PET/CT) and PET/MR in the same session for oncological examination, were retrospectively analyzed. For each patient, raw PET data from PET/MR scanner were reconstructed with 4- and 5-class MRAC maps, generated by hybrid PET/MR system (PET_MRAC4 and PET_MRAC5, respectively, where PET_MRAC is PET images reconstructed using MR-based attenuation correction map), and an AC map derived from CT data after a custom co-registration pipeline (PET_rCTAC, where PET_rCTAC is PET images reconstructed using CT-based attenuation correction map), which served as reference. Mean PET standardized uptake values (
results
conclusionsOur results showed that neglecting bones in AC can underestimate the FDG uptake measurement of the spinal cord. The inclusion of bones in MRAC is far from negligible and improves the AC in spinal cord, mainly at low spinal levels. Therefore, care must be taken in the spinal canal region, and the use of AC map reconstruction methods accounting for bone structures could be beneficial.
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