ArticleJournal of the American Heart Association2021
Prognostic Value of Fractional Excretion of Urea Nitrogen at Discharge in Acute Decompensated Heart Failure.
Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 7 citations in OpenAlex.
- Urinary Biomarkers for the Risk Assessment and Management of Heart Failure: Pearls and Pitfalls.Current heart failure reports · 2026Review
- Comparative Prognostic Value of Four Urinary Biomarkers for Cardiovascular and Renal Outcomes after Transcatheter Aortic Valve Implantation.Cardiorenal medicine · 2026Article
- Impact of non-cardiovascular factors on cardiovascular death in acute decompensated heart failure: Enhancing predictive models with frailty and comorbid constipation-the Constipation and Frailty Augmented AHEAD score.Geriatrics & gerontology international · 2025Article
- Predicting mortality in heart failure: BUN/creatinine ratio in MIMIC-III.Frontiers in cardiovascular medicine · 2025Article
- Fractional excretion of urea nitrogen can identify true worsening renal function in patients with heart failure.ESC heart failure · 2024Article
- Utility of fractional excretion of urea nitrogen in heart failure patients with chronic kidney disease.ESC heart failure · 2023Article
- Left Ventricular Assist Device as a Destination Therapy: Current Situation and the Importance of Patient Selection.Life (Basel, Switzerland) · 2023Review
- New Classification for the Combined Assessment of the Fractional Excretion of Urea Nitrogen and Estimated Plasma Volume Status in Acute Heart Failure.Journal of the American Heart Association · 2023Article
- Bedside Prognostication in Decompensated Heart Failure: No "Easy Button".Journal of the American Heart Association · 2023Article
- Integrating Physiology Into Hyponatremia Algorithms: Moving Beyond Volume Status.Journal of investigative medicine high impact case reportsArticle
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Maintaining euvolemia is crucial for improving prognosis in acute decompensated heart failure (ADHF). Although fractional excretion of urea nitrogen (FEUN) is used as a body fluid volume index in patients with acute kidney injury, the clinical impact of FEUN in patients with ADHF remains unclear. This study aimed to investigate whether FEUN can determine the long-term prognosis in patients with ADHF. Methods and Results We retrospectively identified 466 patients with ADHF who had FEUN measured at discharge between April 2011 and December 2018. The primary endpoint was post-discharge all-cause death. Patients were divided into two groups according to a FEUN cut-off value of 35%, commonly used in pre-renal failure. The FEUN <35% (low-FEUN) group included 224 patients (48.1%), and the all-cause mortality rate for the total cohort was 37.1%. The log-rank test revealed that the low-FEUN group had a significantly higher rate of all-cause death compared to the FEUN equal to or greater than 35% (high-FEUN) group (
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