Observational studyJournal of the American Heart Association2021
Predictive Value of the Cardio-Ankle Vascular Index for Cardiovascular Events in Patients at Cardiovascular Risk.
Observational study in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Predictive significance of cardio ankle vascular index for the assessment of cardiovascular risk in hypertensive patients: A systematic review.Journal of clinical hypertension (Greenwich, Conn.) · 2024Pooled it
- Trial
- Clinical Significance of Cardio-Ankle Vascular Index in Stage A/B Heart Failure Patients With Type 2 Diabetes Mellitus.Journal of clinical medicine research · 2026Article
- Improved Prediction of Cardiovascular Events Using Serial Cardio-Ankle Vascular Index (CAVI) Measurements: A 10-Year Prospective Cohort Study.Clinical cardiology · 2026Article
- Short-term high sodium intake increases nocturnal blood pressure but not arterial stiffness in Black adults.European journal of nutrition · 2026Article
- Subclinical atherosclerosis assessed by cardio-ankle vascular index and carotid intima-media thickness in people living with HIV receiving integrase inhibitor-based tenofovir regimens.BMC infectious diseases · 2026Article
- Article
- Integrating emerging vascular biomarkers into clinical hypertension practice: Reflections on the hypertension research update and perspectives 2025.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Association of Arterial Velocity Pulse Index and Arterial Pressure-Volume Index with Central Arterial Stiffness and Cardiac Function in the Japanese Population.Journal of clinical medicine · 2026Article
- Revisiting the Windkessel Function: Toward Accessible Assessment of Central Arterial Health.Journal of clinical medicine · 2026Article
- Longitudinal Associations Between Metabolic Risk Burden and the Cardio-Ankle Vascular Index (CAVI) in Japan Using Health-Check Cohort.Vascular health and risk management · 2026Article
- Night-to-Day Ratio Specified by 24-hour Blood Pressure Monitoring, Arterial Stiffness and Cardio-Ankle Vascular Index as Predictive Factors of Cardiovascular Risk.Physiological research · 2025Article
- Association Between Cardio-Ankle Vascular Index and Heart Failure Outcomes: Insights From a Prospective Multicenter Cohort.JACC. Advances · 2025Article
- Clinical Significance of the Cardio-Ankle Vascular Index as a Cardiovascular Disease Risk Factor in Japanese Elderly Patients With Obesity.Journal of clinical medicine research · 2025Article
- AI-Induced Vascular Ages Are a Measurable Residual Risk for Cardiovascular Diseases in the Japanese Population.Journal of clinical medicine · 2025Article
- Potential Effects of Sacubitril/Valsartan on the Cardio-ankle Vascular Index in Hypertensive Patients.Internal medicine (Tokyo, Japan) · 2025Observational
- Impact of vascular biomarkers and supine hypertension on cardiovascular outcomes in hypertensive patients: first results from the Cardiovascular Prognostic COUPLING Study in Japan.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Observational
- Cardio-ankle index, ankle-brachial index and supine hypertension for the improved prediction of cardiovascular outcomes in hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Noninvasive Assessment of Vascular Function: From Physiological Tests to Biomarkers.JACC. Asia · 2024Review
- QKD interval as a noninvasive method for evaluation of atherosclerosis.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Arterial stiffness is an important predictor of cardiovascular events; however, indexes for measuring arterial stiffness have not been widely incorporated into routine clinical practice. This study aimed to determine whether the cardio-ankle vascular index (CAVI), based on the blood pressure-independent stiffness parameter β and reflecting arterial stiffness from the origin of the ascending aorta, is a good predictor of cardiovascular events in patients with cardiovascular disease risk factors in a large prospective cohort. Methods and Results This multicenter prospective cohort study, commencing in May 2013, with a 5-year follow-up period, included patients (aged 40‒74 years) with cardiovascular disease risks. The primary outcome was the composite of cardiovascular death, nonfatal stroke, or nonfatal myocardial infarction. Among 2932 included patients, 2001 (68.3%) were men; the mean (SD) age at diagnosis was 63 (8) years. During the median follow-up of 4.9 years, 82 participants experienced primary outcomes. The CAVI predicted the primary outcome (hazard ratio, 1.38; 95% CI, 1.16‒1.65;
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