Evidence map›Paper›PMID 34369192›Full record

ArticleThe Journal of international medical research2021

Exploring the optimal dose of low ionizing radiation to enhance immune function: a rabbit model.

Yuhong Zhang, Hongyan Ren, Yifan Zheng, Qiang Yang, Miao Li, Hongqian Gu, Liguo Hao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yuhong ZhangMedical Imaging Class 17-03, School of Medical Technology, Qiqihar Medical University, Heilongjiang, Qiqihar, China.
Hongyan RenMedical Imaging Class 17-03, School of Medical Technology, Qiqihar Medical University, Heilongjiang, Qiqihar, China.
Yifan ZhengMedical Imaging Class 17-03, School of Medical Technology, Qiqihar Medical University, Heilongjiang, Qiqihar, China.
Qiang YangMedical Imaging Class 17-03, School of Medical Technology, Qiqihar Medical University, Heilongjiang, Qiqihar, China.
Miao LiMedical Imaging Class 17-03, School of Medical Technology, Qiqihar Medical University, Heilongjiang, Qiqihar, China.
Hongqian GuMolecular Imaging Laboratory, School of Medical Technology, Qiqihar Medical University, Heilongjiang, Qiqihar, China.
Liguo HaoMolecular Imaging Laboratory, School of Medical Technology, Qiqihar Medical University, Heilongjiang, Qiqihar, China.ORCID https://orcid.org/0000-0001-6102-4493
Qiqihar Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary liver cancer is one of the most common malignant tumors in China. Currently, immunotherapy for liver cancer is a research hotspot. Experimental studies and epidemiological investigations have confirmed the antineoplastic activity of low ionizing radiation. The aim of this study was to explore the optimal dose of low ionizing radiation to enhance immune function. Twenty-five New Zealand rabbits were randomly divided into five groups (n = 5 each): experimental group 1 (25 mGy), experimental group 2 (50 mGy), experimental group 3 (75 mGy), experimental group 4 (100 mGy), and the control group (0 mGy). VX-2 tumor tissue was injected into rabbits using a high-frequency B-ultrasound probe (3.5 MHz). Rabbits were irradiated, and on day 4 after irradiation, blood was collected from each rabbit. Blood chemistry, interleukin (IL)-4, interferon (IFN)-γ, immunoglobulin (Ig)G, and IgM levels were assessed. On day 15 after irradiation, macrophage phagocytic function was assessed. The rabbits were sacrificed, and the spleen was removed and weighed to calculate its spleen index. Each parameter was highest in the experimental group 3 (75 mGy). Thus, we suspect the optimal low ionizing radiation dose to improve immune function may be 75 mGy.

Indexed as

Radiation, IonizingSpleenAnimalsChinaDose-Response Relationship, RadiationImmunityRabbitsimmune functionimmunoglobulin Gimmunoglobulin Mlow ionizing radiationPrimary liver cancerrabbit model

Identifiers

PMID34369192
PMCPMC8358509
OpenAlexW3191468278

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.