Evidence map›Paper›PMID 34368941›Full record

ArticleInfection2021

Evaluation of a point-of-care molecular detection device for Leishmania spp. and intercurrent fungal and mycobacterial organisms in Peruvian patients with cutaneous ulcers.

Ruwandi Kariyawasam, Braulio M Valencia, Rachel Lau, Eric Shao, Courtney A Thompson, Michael Stevens, Leah Kincaid, Ana Luz Quispe Del Castillo, Lloysi O Cruz-Arzapalo, Alejandro Llanos-Cuentas and 1 more

Abstract read
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Article in Infection, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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  5. Novel CRISPR-based detection ofFrontiers in microbiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 4 countries.

Ruwandi Kariyawasam *Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
Braulio M Valencia *Instituto de Medicina Tropical "Alexander Von Humboldt", Lima, Peru.
Rachel LauPublic Health Ontario Laboratory, Toronto, ON, Canada.
Eric ShaoDepartment of Microbiology and Immunology, Western University, London, ON, Canada.
Courtney A ThompsonDepartment of Medicine, University of Toronto, Toronto, ON, Canada.
Michael StevensDivision of Clinical Dermatology and Cutaneous Science, Department of Medicine, Dalhousie University, Halifax, NS, Canada.
Leah KincaidAlliance Dermatology Associates, Lawrenceville, NJ, USA.
Ana Luz Quispe Del CastilloInstituto de Medicina Tropical "Alexander Von Humboldt", Lima, Peru.
Lloysi O Cruz-ArzapaloHospital de Apoyo Pichanaki, Direccion Regional de Salud, Junin, Peru.
Alejandro Llanos-CuentasInstituto de Medicina Tropical "Alexander Von Humboldt", Lima, Peru.
Andrea K BoggildInstitute of Medical Science, University of Toronto, Toronto, ON, Canada. andrea.boggild@utoronto.ca.ORCID http://orcid.org/0000-0002-2720-6944
University of Toronto · CAAlexander von Humboldt Foundation · DEDalhousie University · CAPublic Health Ontario · CAUniversidad Peruana Cayetano Heredia · PEUNSW Sydney · AUWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOverlapping clinical features of cutaneous leishmaniasis (CL) with ulcers caused by fungi and mycobacteria necessitate confirmatory diagnostic testing. We evaluated a handheld battery-operated device for detection of CL and common fungal and mycobacterial causes of ulcers.

methodsWe validated Palm PCR™ for detection of common ulcerative skin pathogens using ATCC

resultsPalm PCR™ detected 100% of ATCC

conclusionsPalm PCR™ performs comparably to conventional PCR for detection of Leishmania, fungi, and mycobacteria. This work has implications for the diagnostic approach to tropical ulcers, and has the potential to improve field detection of ulcerative pathogens in resource constrained areas.

Indexed as

LeishmaniaLeishmaniasis, CutaneousMycobacteriumFungiHumansPeruPoint-of-Care SystemsSensitivity and SpecificityUlcerCutaneous leishmaniasisFungiMycobacteriumPeruPoint of care diagnosticsTropical ulcer

Identifiers

PMID34368941
OpenAlexW3187731499

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.