Evidence map›Paper›PMID 34368924›Full record

ArticleAnnals of nuclear medicine2021

First clinical assessment of [

Jun Toyohara, Muneyuki Sakata, Kenji Ishibashi, Pascalle Mossel, Masamichi Imai, Kei Wagatsuma, Tetsuro Tago, Etsuko Imabayashi, Nicola A Colabufo, Gert Luurtsema and 1 more

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Annals of nuclear medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. FromACS omega · 2026
    Article
  2. First-in-human PET study of [Journal of translational medicine · 2026
    Article
  3. Designing a Small Molecule for PET Radiotracing: [Molecules (Basel, Switzerland) · 2025
    Review
  4. Article
  5. Oral Administration of [Molecular imaging and biology · 2025
    Article
  6. Quantification of P-glycoprotein function at the human blood-brain barrier using [European journal of nuclear medicine and molecular imaging · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Jun ToyoharaResearch Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan. toyohara@pet.tmig.or.jp.ORCID http://orcid.org/0000-0003-4721-405X
Muneyuki SakataResearch Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan.
Kenji IshibashiResearch Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan.
Pascalle MosselDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
Masamichi ImaiResearch Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan.
Kei WagatsumaResearch Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan.
Tetsuro TagoResearch Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan.
Etsuko ImabayashiDepartment of Diagnostic Radiology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan.
Nicola A ColabufoDipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari, via Orabona 4, 70125, Bari, Italy.
Gert LuurtsemaDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
Kenji IshiiResearch Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan.
Tokyo Metropolitan Institute of Gerontology · JPUniversity Medical Center Groningen · NLTokyo Metropolitan Geriatric Hospital · JPUniversity of Bari Aldo Moro · IT

Funding

Japan Society for the Promotion of Science 18K07658Japan Society for the Promotion of Science 21K07663
6 · The paper itself

Abstract

objective5-(1-(2-[

methods[

resultsNo serious adverse events occurred throughout the study period. Although biodistribution implied hepatobiliary excretion, secretion of radioactivity from liver to small intestine through the gallbladder was very slow. Total renal excreted radioactivity recovered during 6 h after injection was < 2%ID. Absorbed dose was the highest in the pancreas (mean ± SD, 203 ± 45 μGy/MBq) followed by the liver (83 ± 11 μGy/MBq). Mean effective dose with and without urination was 17 ± 1 μSv/MBq. [

conclusionsThis initial evaluation indicated that [

Indexed as

Blood-Brain BarrierFluorine RadioisotopesPositron-Emission TomographyAdultATP Binding Cassette Transporter, Subfamily B, Member 1Healthy VolunteersHumansIsoquinolinesMaleRadioactive TracersRadiometryTissue DistributionYoung AdultATP Binding Cassette Transporter, Subfamily B, Member 1Fluorine-18Fluorine RadioisotopesIsoquinolinesRadioactive TracersBlood–Brain barrierDosimetryFirst-in-humanP-glycoproteinPositron emission tomography

Identifiers

PMID34368924
OpenAlexW3191548761

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.