Evidence map›Paper›PMID 34368883›Full record

ArticleInternational journal of molecular medicine2021

Oxymatrine attenuates oxidized low‑density lipoprotein‑induced HUVEC injury by inhibiting NLRP3 inflammasome‑mediated pyroptosis via the activation of the SIRT1/Nrf2 signaling pathway.

Xin Jin, Wan Fu, Jiaxiu Zhou, Niannian Shuai, Yan Yang, Bo Wang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.

  1. Pooled it
  2. Freeze-DriedBiomolecules · 2026
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  18. The critical role of Sirt1 in ischemic stroke.Frontiers in pharmacology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xin JinDepartment of Anesthesiology, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, P.R. China.
Wan FuDepartment of Neurology, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, P.R. China.
Jiaxiu ZhouDepartment of Anesthesiology, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, P.R. China.
Niannian ShuaiDepartment of Anesthesiology, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, P.R. China.
Yan YangDepartment of Anesthesiology, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, P.R. China.
Bo WangDepartment of Anesthesiology, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, P.R. China.
First Affiliated Hospital of University of South China · CNUniversity of South China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxymatrine, a quinolizidine alkaloid isolated from the traditional Chinese herb

Indexed as

AlkaloidsAntioxidantsCells, CulturedCell SurvivalHumansHuman Umbilical Vein Endothelial CellsInflammasomesLipoproteins, LDLMatrinesNF-E2-Related Factor 2NLR Family, Pyrin Domain-Containing 3 ProteinOxidative StressPyroptosisQuinolizinesReactive Oxygen SpeciesSignal TransductionAlkaloidsAntioxidantsInflammasomesLipoproteins, LDLMatrinesNFE2L2 protein, humanNF-E2-Related Factor 2NLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanoxidized low density lipoproteinoxymatrineQuinolizinesReactive Oxygen SpeciesSIRT1 protein, humanSirtuin 1atherosclerosisendothelial cell injuryNLRP3 inflammasome‑mediated pyroptosisoxymatrinesirtuin 1/nuclear factor‑erythroid 2‑related factor 2 signaling pathway

Identifiers

PMID34368883
PMCPMC8416146
OpenAlexW3190104221

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.