Evidence map›Paper›PMID 34368855›Full record

ArticleInternational journal of molecular medicine2021

HO‑1 knockdown upregulates the expression of VCAM‑1 to induce neutrophil recruitment during renal ischemia‑reperfusion injury.

Yecheng He, Huadong Li, Juan Yao, Hua Zhong, Yanbin Kuang, Xin Li, Weihua Bian

Abstract read
In one paragraph

Article in International journal of molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
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  11. Review
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  13. Immune response associated with ischemia and reperfusion injury during organ transplantation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yecheng He *Department of Clinical Medicine, Suzhou Vocational Health College, Suzhou, Jiangsu 215009, P.R. China.
Huadong Li *Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Juan Yao *Department of Nursing, Suzhou Vocational Health College, Suzhou, Jiangsu 215009, P.R. China.
Hua ZhongCollege of Life Sciences, Wuhan University, Wuhan, Hubei 430072, P.R. China.
Yanbin KuangDepartment of Respiratory Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200123, P.R. China.
Xin LiKey Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310024, P.R. China.
Weihua BianDepartment of Cell Biology, Binzhou Medical University, Yantai, Shandong 264003, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heme oxygenase‑1 (HO‑1) has been reported to be upregulated following renal ischemia‑reperfusion injury (IRI) and plays a key cytoprotective role; however, the underlying molecular mechanisms of its protective effects remain poorly understood. In the present study, in order to further elucidate the molecular mechanisms underlying the cytoprotective role of HO‑1 in renal IRI, HO‑1

Indexed as

AnimalsBlood Urea NitrogenCreatinineHeme Oxygenase-1InflammationKidneyKidney DiseasesMaleMembrane ProteinsMiceNeutrophilsReperfusion InjuryUp-RegulationVascular Cell Adhesion Molecule-1CreatinineHeme Oxygenase-1Hmox1 protein, mouseMembrane ProteinsVascular Cell Adhesion Molecule-1adhesionheme oxygenase‑1migrationneutrophil recruitmentrenal ischemia‑reperfusion injuryvascular cell adhesion molecule‑1

Identifiers

PMID34368855
PMCPMC8416149

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.