Evidence map›Paper›PMID 34368846›Full record

ArticleThe Journal of antimicrobial chemotherapy2021

Modified methicillin-resistant Staphylococcus aureus detected in neonatal intensive care patients.

Melissa R Gitman, Bremy Alburquerque, Marilyn Chung, Adriana van de Guchte, Mitchell J Sullivan, Ajay Obla, Jose Polanco, Irina Oussenko, Melissa L Smith, Flora Samaroo and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of antimicrobial chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Frequency and Molecular Characterization ofLife (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Melissa R GitmanDepartment of Pathology and Laboratory Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.ORCID 0000-0002-6960-0763
Bremy AlburquerqueDepartment of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Marilyn ChungDepartment of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Adriana van de GuchteDepartment of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Mitchell J SullivanDepartment of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Ajay OblaDepartment of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Jose PolancoDepartment of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Irina OussenkoDepartment of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Melissa L SmithDepartment of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Flora SamarooDepartment of Pathology and Laboratory Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Debbie BarackmanDepartment of Pathology and Laboratory Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Deena R AltmanDepartment of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.ORCID 0000-0003-1948-3834
Emilia Mia SordilloDepartment of Pathology and Laboratory Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Harm van BakelDepartment of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.ORCID 0000-0002-1376-6916
Icahn School of Medicine at Mount Sinai · USThe Graduate Center, CUNY · US

Funding

Investigating genomic factors and microbiome features that impact CDI transmission and prognosisR01AI119145 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BASHIR, ALI M, VAN BAKEL, HARM · 2015 to 2019
$4.2M
Big Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0M
NIAID NIH HHS R01 AI119145NIAID NIH HHS R01AI119145NIH HHS S10 OD026880
6 · The paper itself

Abstract

objectivesAs part of an active MRSA surveillance programme in our neonatal ICU, we identified nares surveillance cultures from two infants that displayed heterogeneity in methicillin resistance between isolated subclones that lacked mecA and mecC.

methodsThe underlying mechanism for the modified Staphylococcus aureus (MODSA) methicillin-resistance phenotype was investigated by WGS.

resultsComparison of finished-quality genomes of four MODSA and four MSSA subclones demonstrated that the resistance changes were associated with unique truncating mutations in the gene encoding the cyclic diadenosine monophosphate phosphodiesterase enzyme GdpP or a non-synonymous substitution in the gene encoding PBP2.

conclusionsThese two cases highlight the difficulty in identifying non-mecA, non-mecC-mediated MRSA isolates in the clinical microbiology laboratory, which leads to difficulties in implementing appropriate therapy and infection control measures.

Indexed as

Methicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsAnti-Bacterial AgentsBacterial ProteinsHumansInfant, NewbornIntensive Care, NeonatalMicrobial Sensitivity TestsStaphylococcus aureusAnti-Bacterial AgentsBacterial Proteins

Identifiers

PMID34368846
PMCPMC8521402
OpenAlexW3136309841

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.