Evidence map›Paper›PMID 34368799›Full record

ArticleGlomerular diseases2021

Effect of a gluten-free diet on albuminuria in children with newly diagnosed celiac disease.

Jeremiah Levine, Leora Hauptman, Libia Moy, Howard Trachtman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Glomerular diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jeremiah LevineNYU Langone Health, Department of Pediatrics, Divisions of Gastroenterology, New York, NY.
Leora HauptmanNYU Langone Health, Department of Pediatrics, Divisions of Gastroenterology, New York, NY.
Libia MoyNYU Langone Health, Department of Pediatrics, Divisions of Gastroenterology, New York, NY.
Howard TrachtmanNYU Langone Health, Department of Pediatrics, Divisions Nephrology, New York, NY.
NYU Langone Health · US

Funding

Developmental Origins of Kidney Function in Early Life and Environmental RisksR01ES032214 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MALAGA-DIEGUEZ, LAURA, TRASANDE, LEONARDO · 2020 to 2024
$3.5M
Environmental Oxidant Stressors in Pediatric Chronic Kidney Disease - ResubmissioR01DK100307 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TRACHTMAN, HOWARD, TRASANDE, LEONARDO · 2014 to 2018
$2.5M
NIDDK NIH HHS R01 DK100307NIEHS NIH HHS R01 ES032214
6 · The paper itself

Abstract

BACKGROUND AND

objectivesAltered gastrointestinal permeability in celiac disease (CD) is mediated by zonulin. The receptor for zonulin is expressed on podocytes. Therefore, we tested the effect of a gluten-free diet (GFD) on albuminuria in pediatric patients with newly diagnosed CD.

methodsWe performed a cohort study comparing urinary albumin (μg):creatinine (mg) ratio (ACR) in CD patients vs controls and in response to a GFD.

resultsChildren with CD (n=46) had higher ACR compared to controls (n=21), 20.2±5.6 versus 8.4±1.1 μg/mg, P=0.16 and exceeded 30 μg/mg (microalbuminuria cut-off) in 7/46 cases. 17 patients had a follow-up assessment (interval 6.1±0.7 months) on a GFD. Baseline ACR was 20.7±5.2 that fell to 10.4±1.5 μg/mg, P=0.035.

conclusionChildren and adolescents with newly diagnosed CD have low-grade albuminuria that is numerically higher than controls and that declined after implementation of a GFD. CD may be associated with reversible defects in the glomerular barrier.

Indexed as

albuminuriaceliac diseaseglomerular permeabilitygluten-free diet

Identifiers

PMID34368799
PMCPMC8336695
OpenAlexW3148029910

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.