Evidence map›Paper›PMID 34368774›Full record

ArticleAnnual review of developmental psychology2020

Development of ADHD: Etiology, Heterogeneity, and Early Life Course.

Joel T Nigg, Margaret H Sibley, Anita Thapar, Sarah L Karalunas

Abstract read
In one paragraph

Article in Annual review of developmental psychology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Rising ADHD medication use, persistent gaps in treatment.The Lancet regional health. Europe · 2026
    Article
  19. Article
  20. Article

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Joel T NiggOregon Health & Science University, Portland OR, USA.
Margaret H SibleyUniversity of Washington and Seattle Children's Research Institute, Seattle WA, USA.
Anita ThaparCardiff University, Cardiff Wales, UK.
Sarah L KaralunasOregon Health & Science University, Portland OR, USA.

Funding

ADHD heterogeneity, mechanisms, and risk profileR37MH059105 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI NIGG, JOEL T · 2014 to 2023
$7.0M
Developmental origins and early detection of ADHD and dysregulatory psychopathologyR01MH124824 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI SULLIVAN, ELINOR L. · 2021 to 2025
$3.8M
The Impact of Maternal Obesity and Poor Antenatal Nutrition on Offspring RDoC Dimensions and Risk for Neurodevelopmental DisordersR01MH117177 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI NIGG, JOEL T, SULLIVAN, ELINOR L. · 2018 to 2022
$3.6M
NEUROPSYCHOLOGICAL AND FAMILIAL MARKERS FOR CHILD ADHDR01MH059105 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI NIGG, JOEL T · 1999 to 2012
$3.3M
Biobehavioral validation of the ADHD emotion dysregulation phenotypeR01MH120109 · NIMH · PURDUE UNIVERSITY · PI KARALUNAS, SARAH LYN · 2020 to 2025
$2.9M
Medical Research Council MR/L010305/1NIMH NIH HHS R01 MH059105NIMH NIH HHS R01 MH117177NIMH NIH HHS R01 MH120109NIMH NIH HHS R01 MH124824NIMH NIH HHS R37 MH059105
6 · The paper itself

Abstract

ADHD represents a powerful entry point for developmental approaches to psychopathology due to its major role in early emergence of major life problems. One key issue concerns the role of early environmental risks in etiology and maintenance in the context of genetic liability. Here, psychosocial aspects of development need more attention. A second key issue is that phenotypic heterogeneity requires better resolution if actionable causal mechanisms are to be effectively identified. Here, the interplay of cognition and emotion in the context of a temperament lens is one helpful way forward. A third key issue is the poorly understood yet somewhat striking bifurcation of developmental course in adolescence, when a subgroup seem to have largely benign outcomes, while a larger group continue on a problematic path. A final integrative question concerns the most effective conceptualization of the disorder in relation to broader dysregulation. Key scientific priorities are noted.

Indexed as

ADHDadolescent developmentAttention Deficit Disorder with Hyperactivitydevelopmentexecutive functionstemperament

Identifiers

PMID34368774
PMCPMC8336725

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.