ArticleACS applied polymer materials2021
Automated PET-RAFT Polymerization Towards Pharmaceutical Amorphous Solid Dispersion Development.
Article in ACS applied polymer materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Beyond Traditional RAFT Polymerization: Emerging Strategies and Future Perspectives; A Third Update.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Machine Learning in Polymer Research.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Data-Driven Design of Novel Polymer Excipients for Pharmaceutical Amorphous Solid Dispersions.Bioconjugate chemistry · 2024Article
- Recent developments in visible light induced polymerization towards its application to nanopores.Chemical communications (Cambridge, England) · 2023Review
- A fully automated platform for photoinitiated RAFT polymerization.Digital discovery · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
In pharmaceutical oral drug delivery development, about 90% of drugs in the pipeline have poor aqueous solubility leading to severe challenges with oral bioavailability and translation to effective and safe drug products. Amorphous solid dispersions (ASDs) have been utilized to enhance the oral bioavailability of poorly soluble active pharmaceutical ingredients (APIs). However, a limited selection of regulatory-approved polymer excipients exists for the development and further understanding of tailor-made ASDs. Thus, a significant need exists to better understand how polymers can be designed to interact with specific API moieties. Here, we demonstrate how an automated combinatorial library approach can be applied to the synthesis and screening of polymer excipients for the model drug probucol. We synthesized a library of 25 random heteropolymers containing one hydrophilic monomer (2-hydroxypropyl acrylate (HPA)) and four hydrophobic monomers at varied incorporation. The performance of ASDs made by a rapid film casting method was evaluated by dissolution using ultra-performance liquid chromatography (UPLC) sampling at various time points. This combinatorial library and rapid screening strategy enabled us to identify a relationship between polymer hydrophobicity, monomer hydrophobic side group geometry, and API dissolution performance. Remarkably, the most effective synthesized polymers displayed slower drug release kinetics compared to industry standard polymer excipients, showing the ability to modulate the drug release profile. Future coupling of high throughput polymer synthesis, high throughput screening (HTS), and quantitative modeling would enable specification of designer polymer excipients for specific API functionalities.
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Registered trials
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