ArticleInfection prevention in practice2020
Auditing use of antibiotics in Zimbabwean neonates.
Article in Infection prevention in practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Strategies to reduce antimicrobial resistance in newborns in low-income and middle-income countries: a systematic review and meta-analysis.The Lancet. Global health · 2026Pooled it
- Prevention and Treatment of Neonatal Infections in Facility and Community Settings of Low- and Middle-Income Countries: A Descriptive Review.Neonatology · 2025Pooled it
- Article
- Antibiotic stewardship and point-of-care testing for children in 25 low-income and lower-middle-income countries: a systematic review and meta-analysis.EClinicalMedicine · 2025Article
- Parental involvement in infection prevention and control in low- and middle-income country neonatal units: a scoping review protocol.BMJ open · 2025Article
- Clinical prediction models to diagnose neonatal sepsis in low-income and middle-income countries: a scoping review.BMJ global health · 2025Article
- Frequency and types of antibiotic usage in a referral neonatal intensive care unit, based on the world health organization classification (AwaRe).BMC pediatrics · 2025Article
- Rapid bacterial identification and resistance detection using a low complexity molecular diagnostic platform in Zimbabwe.PLOS global public health · 2025Article
- Blood culture versus antibiotic use for neonatal inpatients in 61 hospitals implementing with the NEST360 Alliance in Kenya, Malawi, Nigeria, and Tanzania: a cross-sectional study.BMC pediatrics · 2023Article
- Diagnosing early-onset neonatal sepsis in low-resource settings: development of a multivariable prediction model.Archives of disease in childhood · 2023Article
- Development and implementation experience of a learning healthcare system for facility based newborn care in low resource settings: The Neotree.Learning health systems · 2023Article
- Infection Prevention and Control in low-resource settings: the need for the local, the contextual and the pragmatic.Infection prevention in practice · 2022Article
- Evaluation of a Novel Culture System for Rapid Pathogen Identification and Detection of Cephalosporin Resistance in Neonatal Gram-negative Sepsis at a Tertiary Referral Unit in Harare, Zimbabwe.The Pediatric infectious disease journal · 2021Article
- Learning from pragmatic local research.Infection prevention in practice · 2021Article
- Electronic application to improve management of infections in low-income neonatal units: pilot implementation of the NeoTree beta app in a public sector hospital in Zimbabwe.BMJ open quality · 2021Article
- Admissions to a Low-Resource Neonatal Unit in Malawi Using a Mobile App and Dashboard: A 1-Year Digital Perinatal Outcome Audit.Frontiers in digital health · 2021Article
- Article
- Review of Drug Utilization Studies in Neonatal Units: A Global Perspective.International journal of environmental research and public health · 2020Review
- Pattern of hospital antibiotic use in term neonates using WHO Access, Watch and Reserve Classification (AWaRe).Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundNeonatal sepsis is a major cause of morbidity and mortality in low-income settings. As signs of sepsis are non-specific and deterioration precipitous, antibiotics are often used profusely in these settings where diagnostics may not be readily available. Harare Central Hospital, Zimbabwe, delivers 12000 babies per annum admitting ∼4800 to the neonatal unit. Overcrowding, understaffing and rapid staff turnover are consistent problems. Suspected sepsis is highly prevalent, and antibiotics widely used. We audited the impact of training and benchmarking intervention on rationalizing antibiotic prescription using local, World Health Organization-derived, guidelines as the standard.
methodsAn initial audit of admission diagnosis and antibiotic use was performed between 8
resultsSepsis was the most common admitting diagnosis by interns at both time points but reduced at repeat audit (81% versus 59%,
conclusionA substantial decrease in antibiotic use was achieved by performance feedback, training and leadership, although ongoing performance review will be key to ensuring safety and sustainability.
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