Evidence map›Paper›PMID 34368642›Full record

ArticleACS applied bio materials2020

Surface-grafted zwitterionic polymers improve the efficacy of a single antibiotic injection in suppressing

Ben Zhang, Jordan D Skelly, Benjamin M Braun, David C Ayers, Jie Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied bio materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ben ZhangDepartment of Orthopedics & Physical Rehabilitation, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Jordan D SkellyDepartment of Orthopedics & Physical Rehabilitation, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Benjamin M BraunDepartment of Orthopedics & Physical Rehabilitation, University of Massachusetts Medical School, Worcester, MA 01655, USA.
David C AyersDepartment of Orthopedics & Physical Rehabilitation, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Jie SongDepartment of Orthopedics & Physical Rehabilitation, University of Massachusetts Medical School, Worcester, MA 01655, USA.

Funding

Implant surface modification strategies against periprosthetic infectionsR01AR068418 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SONG, JIE · 2015 to 2019
$1.8M
NIAMS NIH HHS R01 AR068418
6 · The paper itself

Abstract

Implant-associated bacterial infections are difficult to treat due to the tendency of biofilm formation on implant surfaces, which protects embedded pathogens from host defense and impedes antibiotic penetration, rendering systemic antibiotic injections ineffective. Here, we test the hypothesis that implant coatings that reduce bacterial colonization would make planktonic bacteria within the periprosthetic environment more susceptible to conventional systemic antibiotic treatment. We covalently grafted zwitterionic polymer brushes poly(sulfobetaine methacryate) from Ti6Al4V surface to increase the substrate surface hydrophilicity and reduce

Indexed as

anti-foulingbacterial colonization on surfacesosteomyelitisperiprosthetic infectionsplanktonic bacteriaStaphylococcus aureuszwitterionic polymer brush

Identifiers

PMID34368642
PMCPMC8340630

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.