Evidence map›Paper›PMID 34368641›Full record

ArticleACS applied bio materials2020

Cowpea Mosaic Virus (CPMV)-Based Cancer Testis Antigen NY-ESO-1 Vaccine Elicits an Antigen-Specific Cytotoxic T Cell Response.

Bindi K Patel, Chao Wang, Braulio Lorens, Alan D Levine, Nicole F Steinmetz, Sourabh Shukla

Open access · greenAbstract read
In one paragraph

Article in ACS applied bio materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Nanovaccines empowering CD8Theranostics · 2025
    Review
  5. Plant-Derived Anti-Cancer Therapeutics and Biopharmaceuticals.Bioengineering (Basel, Switzerland) · 2024
    Review
  6. Nanoparticle-Mediated Immunotherapy in Triple-Negative Breast Cancer.ACS biomaterials science & engineering · 2024
    Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
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  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Bindi K PatelDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Chao WangDepartment of NanoEngineering, University of California-San Diego, La Jolla, California 92093, United States.
Braulio LorensDepartment of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Alan D LevineDepartment of Molecular Biology and Microbiology and Medicine, Pediatrics Pathology, and Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Nicole F SteinmetzDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, United States.ORCID 0000-0002-0130-0481
Sourabh ShuklaDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, United States.ORCID 0000-0001-9751-5833
Case Western Reserve University · USUniversity of California San Diego · US

Funding

Identification of immune protective pathways dysregulated by opioid use in HIV infection, using a systems biology-based approach, toward the goal of pharmacological restoration of immune functionR01DA043253 · NIDA · CASE WESTERN RESERVE UNIVERSITY · PI LEVINE, ALAN DAVID · 2016 to 2021
$4.3M
Dual-pronged nano-drug delivery using plant virus-like particles.R01CA224605 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Nicole Franziska Steinmetz · 2017 to 2026
$4.0M
NCI NIH HHS R01 CA224605NIDA NIH HHS R01 DA043253
6 · The paper itself

Abstract

Cancer vaccines are promising adjuvant immunotherapies that can stimulate the immune system to recognize tumor-associated antigens and eliminate the residual or recurring disease. The aberrant and restricted expression of highly immunogenic cancer testis antigen NY-ESO-1 in several malignancies, including triple-negative breast cancer, melanoma, myelomas, and ovarian cancer, makes NY-ESO-1 an attractive antigenic target for cancer vaccines. This study describes a NY-ESO-1 vaccine based on a bio-inspired nanomaterial platform technology, specifically a plant virus nanoparticle. The 30 nm icosahedral plant virus cowpea mosaic virus (CPMV) displaying multiple copies of human HLA-A2 restricted peptide antigen NY-ESO-1

Indexed as

cancer testis antigencancer vaccinecowpea mosaic virusNY-ESO-1 antigenplant virusviral nanotechnology

Identifiers

PMID34368641
PMCPMC8340627
OpenAlexW3036999309

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.