Evidence map›Paper›PMID 34368631›Full record

ArticleJournal of Alzheimer's disease reports2021

Intrinsic Aerobic Capacity Affects Hippocampal pAkt and HSP72 Response to an Acute High Fat Diet and Heat Treatment in Rats.

Li Gan, Xiaonan Wan, Delin Ma, Fu-Chen Yang, Jingpeng Zhu, Robert S Rogers, Joshua L Wheatley, Lauren G Koch, Steven L Britton, John P Thyfault and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Li GanDepartment of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Xiaonan WanThe Second Clinical Medical College of Nanchang University, Nanchang, Jiangxi, China.
Delin MaDepartment of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA.
Fu-Chen YangDepartment of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA.
Jingpeng ZhuThe Second Clinical Medical College of Nanchang University, Nanchang, Jiangxi, China.
Robert S RogersDepartment of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA.
Joshua L WheatleyDepartment of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA.
Lauren G KochDepartment of Physiology and Pharmacology, The University of Toledo, Toledo, OH, USA.
Steven L BrittonDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
John P ThyfaultDepartment of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA.
Paige C GeigerDepartment of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA.
John A StanfordDepartment of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA.
University of Kansas Medical Center · USNanchang University · CNUniversity of Michigan · USUniversity of Toledo · US

Funding

Using PCORnet to Expand the DS-CONNECT Cohort Through Healthcare System Recruitment, Incorporating Electronic Health Records, and Assessing Self-DeterminationU54HD090216 · NICHD · UNIVERSITY OF KANSAS LAWRENCE · PI COLOMBO, JOHN A. · 2016 to 2020
$6.2M
Resource for Rat Genetic Models of Aerobic CapacityP40OD021331 · OD · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI KOCH, LAUREN GERARD · 2015 to 2019
$1.9M
Aerobic fitness, mitochondrial dysfunction, and fatty liver diseaseR01DK088940 · NIDDK · UNIVERSITY OF MISSOURI-COLUMBIA · PI THYFAULT, JOHN P · 2011 to 2015
$1.5M
Targeting stress-mediated pathways in the treatment of muscle insulin resistanceR01AG031575 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI GEIGER, PAIGE C · 2010 to 2014
$1.2M
NIA NIH HHS R01 AG031575NICHD NIH HHS U54 HD090216NIDDK NIH HHS R01 DK088940NIH HHS P40 OD021331
6 · The paper itself

Abstract

backgroundAerobic capacity is associated with metabolic, cardiovascular, and neurological health. Low-capacity runner (LCR) rats display low aerobic capacity, metabolic dysfuction, and spatial memory deficits. A heat treatment (HT) can improve metabolic dysfunction in LCR peripheral organs after high fat diet (HFD). Little is known about metabolic changes in the brains of these rats following HT.

objectiveOur objective was to examine the extent to which high or low aerobic capacity impacts Akt (a protein marker of metabolism) and heat shock protein 72 (HSP72, a marker of heat shock response) after HFD and HT in hippocampus.

methodsWe measured phosphorylated Akt (pAkt) in the striatum and hippocampus, and HSP72 in the hippocampus, of HFD-fed and chow-fed LCR and high-capacity runner (HCR) rats with and without HT.

resultspAkt was lower in the hippocampus of chow-fed LCR than HCR rats. HFD resulted in greater pAkt in LCR but not HCR rats, but HT resulted in lower pAkt in the LCR HFD group. HSP72 was greater in both HCR and LCR rat hippocampus after HT. The HFD blunted this effect in LCR compared to HCR hippocampus.

conclusionThe abnormal phosphorylation of Akt and diminished HSP response in the hippocampus of young adult LCR rats might indicate early vulnerability to metabolic challenges in this key brain region associated with learning and memory.

Indexed as

Acute high fat dietAktheat treatmentintrinsic aerobic running capacity

Identifiers

PMID34368631
PMCPMC8293662
OpenAlexW3166199477

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.