Evidence map›Paper›PMID 34368630›Full record

ArticleJournal of Alzheimer's disease reports2021

Fifteen Years of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study: Progress and Observations from 2,359 Older Adults Spanning the Spectrum from Cognitive Normality to Alzheimer's Disease.

Christopher Fowler, Stephanie R Rainey-Smith, Sabine Bird, Julia Bomke, Pierrick Bourgeat, Belinda M Brown, Samantha C Burnham, Ashley I Bush, Carolyn Chadunow, Steven Collins and 54 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

64 authors.

Christopher FowlerThe Florey Institute, The University of Melbourne, Parkville, VIC, Australia.
Stephanie R Rainey-SmithCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Sabine BirdCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Julia BomkeAustralian E-Health Research Centre, CSIRO Health & Biosecurity, Herston, QLD, Australia.
Pierrick BourgeatAustralian E-Health Research Centre, CSIRO Health & Biosecurity, Herston, QLD, Australia.
Belinda M BrownAustralian Alzheimer's Research Foundation (Ralph and Patricia Sarich Neuroscience Research Institute), Nedlands, WA, Australia.
Samantha C BurnhamAustralian E-Health Research Centre, CSIRO Health & Biosecurity, Herston, QLD, Australia.
Ashley I BushThe Florey Institute, The University of Melbourne, Parkville, VIC, Australia.
Carolyn ChadunowThe Florey Institute, The University of Melbourne, Parkville, VIC, Australia.
Steven CollinsThe Florey Institute, The University of Melbourne, Parkville, VIC, Australia.
James DoeckeAustralian E-Health Research Centre, CSIRO Health & Biosecurity, Herston, QLD, Australia.
Vincent DoréAustralian E-Health Research Centre, CSIRO Health & Biosecurity, Herston, QLD, Australia.
Kathryn A EllisThe Florey Institute, The University of Melbourne, Parkville, VIC, Australia.
Lis EveredDepartment of Anaesthesia and Acute Pain Medicine, St Vincent's Hospital Melbourne, Victoria Parade, Fitzroy, VIC, Australia.
Amir FazlollahiAustralian E-Health Research Centre, CSIRO Health & Biosecurity, Herston, QLD, Australia.
Jurgen FrippAustralian E-Health Research Centre, CSIRO Health & Biosecurity, Herston, QLD, Australia.
Samantha L GardenerCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Simon GibsonAustralian E-Health Research Centre, CSIRO Health & Biosecurity, Herston, QLD, Australia.
Robert GrenfellAustralian E-Health Research Centre, CSIRO Health & Biosecurity, Herston, QLD, Australia.
Elise HarrisonThe Florey Institute, The University of Melbourne, Parkville, VIC, Australia.
Richard HeadAustralian E-Health Research Centre, CSIRO Health & Biosecurity, Herston, QLD, Australia.
Liang JinThe Florey Institute, The University of Melbourne, Parkville, VIC, Australia.
Adrian KamerThe Florey Institute, The University of Melbourne, Parkville, VIC, Australia.
Fiona LambDepartment of Molecular Imaging and Therapy, Austin Health, Heidelberg, VIC, Australia.
Nicola T LautenschlagerUniversity of Melbourne Academic Unit for Psychiatry of Old Age, Parkville, VIC, Australia.
Simon M LawsCollaborative Genomics and Translation Group, Centre for Precision Health, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Qiao-Xin LiThe Florey Institute, The University of Melbourne, Parkville, VIC, Australia.
Lucy LimCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Yen Ying LimThe Florey Institute, The University of Melbourne, Parkville, VIC, Australia.
Andrea LoueyThe Florey Institute, The University of Melbourne, Parkville, VIC, Australia.
S Lance MacaulayAustralian E-Health Research Centre, CSIRO Health & Biosecurity, Herston, QLD, Australia.
Lucy MackintoshThe Florey Institute, The University of Melbourne, Parkville, VIC, Australia.
Ralph N MartinsCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Paul MaruffCogstate Limited, Melbourne, VIC, Australia.
Colin L MastersThe Florey Institute, The University of Melbourne, Parkville, VIC, Australia.
Simon McBrideAustralian E-Health Research Centre, CSIRO Health & Biosecurity, Herston, QLD, Australia.
Lidija MilicicCollaborative Genomics and Translation Group, Centre for Precision Health, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Madeline PerettiCollaborative Genomics and Translation Group, Centre for Precision Health, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Kelly PertileThe Florey Institute, The University of Melbourne, Parkville, VIC, Australia.
Tenielle PorterCollaborative Genomics and Translation Group, Centre for Precision Health, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Morgan RadlerThe Florey Institute, The University of Melbourne, Parkville, VIC, Australia.
Alan RembachThe Florey Institute, The University of Melbourne, Parkville, VIC, Australia.
Joanne RobertsonThe Florey Institute, The University of Melbourne, Parkville, VIC, Australia.
Mark RodriguesCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Christopher C RoweDepartment of Molecular Imaging and Therapy, Austin Health, Heidelberg, VIC, Australia.
Rebecca RumbleThe Florey Institute, The University of Melbourne, Parkville, VIC, Australia.
Olivier SalvadoCSIRO Data61, Brisbane, QLD, Australia.
Greg SavageDepartment of Psychology, Macquarie University, Sydney, NSW, Australia.
Brendan SilbertDepartment of Anaesthesia and Acute Pain Medicine, St Vincent's Hospital Melbourne, Victoria Parade, Fitzroy, VIC, Australia.
Magdalene SohCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Hamid R SohrabiAustralian Alzheimer's Research Foundation (Ralph and Patricia Sarich Neuroscience Research Institute), Nedlands, WA, Australia.
Kevin TaddeiCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Tania TaddeiCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Christine ThaiThe Florey Institute, The University of Melbourne, Parkville, VIC, Australia.
Brett TrounsonThe Florey Institute, The University of Melbourne, Parkville, VIC, Australia.
Regan TyrrellDepartment of Molecular Imaging and Therapy, Austin Health, Heidelberg, VIC, Australia.
Michael VacherAustralian E-Health Research Centre, CSIRO Health & Biosecurity, Herston, QLD, Australia.
Shiji VargheseThe Florey Institute, The University of Melbourne, Parkville, VIC, Australia.
Victor L VillemagneDepartment of Molecular Imaging and Therapy, Austin Health, Heidelberg, VIC, Australia.
Michael WeinbornCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Michael WoodwardDepartment of Geriatric Medicine Austin Hospital, Heidelberg, VIC, Australia.
Ying XiaAustralian E-Health Research Centre, CSIRO Health & Biosecurity, Herston, QLD, Australia.
David AmesThe Florey Institute, The University of Melbourne, Parkville, VIC, Australia.
the AIBL investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Australian Imaging, Biomarkers and Lifestyle (AIBL) Study commenced in 2006 as a prospective study of 1,112 individuals (768 cognitively normal (CN), 133 with mild cognitive impairment (MCI), and 211 with Alzheimer's disease dementia (AD)) as an 'Inception cohort' who underwent detailed ssessments every 18 months. Over the past decade, an additional 1247 subjects have been added as an 'Enrichment cohort' (as of 10 April 2019).

objectiveHere we provide an overview of these Inception and Enrichment cohorts of more than 8,500 person-years of investigation.

methodsParticipants underwent reassessment every 18 months including comprehensive cognitive testing, neuroimaging (magnetic resonance imaging, MRI; positron emission tomography, PET), biofluid biomarkers and lifestyle evaluations.

resultsAIBL has made major contributions to the understanding of the natural history of AD, with cognitive and biological definitions of its three major stages: preclinical, prodromal and clinical. Early deployment of Aβ-amyloid and tau molecular PET imaging and the development of more sensitive and specific blood tests have facilitated the assessment of genetic and environmental factors which affect age at onset and rates of progression.

conclusionThis fifteen-year study provides a large database of highly characterized individuals with longitudinal cognitive, imaging and lifestyle data and biofluid collections, to aid in the development of interventions to delay onset, prevent or treat AD. Harmonization with similar large longitudinal cohort studies is underway to further these aims.

Indexed as

Alzheimer’s diseaseAβ-amyloid imagingbiomarkerscognitioncohort studylifestylemild cognitive impairmentobservational longitudinalpreclinical Alzheimer’s diseaseprodromal Alzheimer’s disease

Identifiers

PMID34368630
PMCPMC8293663

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.