Evidence map›Paper›PMID 34368469›Full record

ArticleBiochemistry and biophysics reports2021

Effect of pulsatile stretch on unfolded protein response in a new model of the pulmonary hypertensive vascular wall.

Martha Hinton, Elwasila Eltayeb, Saeid Ghavami, Shyamala Dakshinamurti

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Autophagy unraveled: Navigating cell fate and disease dynamics.Biochemistry and biophysics reports · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Martha HintonBiology of Breathing Group, Children's Hospital Research Institute of Manitoba, 513 - 715 McDermot Avenue, Winnipeg, Canada, R3E 3P4.
Elwasila EltayebSection of Neonatology, Department of Pediatrics, University of Manitoba, Health Sciences Centre, 820 Sherbrook Street, Winnipeg, Canada, R3A 1R9.
Saeid GhavamiBiology of Breathing Group, Children's Hospital Research Institute of Manitoba, 513 - 715 McDermot Avenue, Winnipeg, Canada, R3E 3P4.
Shyamala DakshinamurtiBiology of Breathing Group, Children's Hospital Research Institute of Manitoba, 513 - 715 McDermot Avenue, Winnipeg, Canada, R3E 3P4.
Manitoba Health · CAResearch Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Persistent pulmonary hypertension of the newborn (PPHN) is characterized by hypoxemia and arterial remodeling. Dynamic stretch and recoil of the arterial wall during pulsation (in normal conduit arteries, stretch 20% above diastolic diameter) maintains homeostasis; a static arterial wall is associated with remodeling. PPHN is diagnosed by echocardiography as decreased pulmonary artery wall displacement during systole, causing decreased pulmonary arterial pressure acceleration time in a stiff artery. We hypothesized that a 'normal' amplitude of pulsatile stretch is protective against ER stress, while the loss of stretch is a trigger for hypoxia-induced stress responses. Using a novel

Indexed as

ER stressPulmonary arteryPulsatile stretchUnfolded protein response

Identifiers

PMID34368469
PMCPMC8326203
OpenAlexW3183148133

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.