Evidence map›Paper›PMID 34368417›Full record

ArticleAlzheimer's & dementia (New York, N. Y.)2021

Longitudinal naming and repetition relates to AD pathology and burden in autopsy-confirmed primary progressive aphasia.

Katheryn A Q Cousins, Jessica Bove, Lucia A A Giannini, Nikolas G Kinney, Yvonne R Balgenorth, Katya Rascovsky, Edward B Lee, John Q Trojanowski, Murray Grossman, David J Irwin

Abstract read
In one paragraph

Article in Alzheimer's & dementia (New York, N. Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Automatic classification of AD pathology in FTD phenotypes using natural speech.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Katheryn A Q CousinsFrontotemporal Degeneration Center, Perelman School of Medicine Department of Neurology Philadelphia Pennsylvania USA.
Jessica BoveDepartment of Clinical and Health Psychology University of Florida Gainesville Florida USA.
Lucia A A GianniniAlzheimer Center Department of Neurology Erasmus Medical Center Rotterdam the Netherlands.
Nikolas G KinneyFrontotemporal Degeneration Center, Perelman School of Medicine Department of Neurology Philadelphia Pennsylvania USA.
Yvonne R BalgenorthFrontotemporal Degeneration Center, Perelman School of Medicine Department of Neurology Philadelphia Pennsylvania USA.
Katya RascovskyFrontotemporal Degeneration Center, Perelman School of Medicine Department of Neurology Philadelphia Pennsylvania USA.
Edward B LeeTranslational Neuropathology Research Laboratory Perelman School of Medicine Department of Pathology and Laboratory Medicine Philadelphia Pennsylvania USA.
John Q TrojanowskiCenter for Neurodegenerative Disease Research Perelman School of Medicine Department of Pathology and Laboratory Medicine Philadelphia Pennsylvania USA.
Murray GrossmanFrontotemporal Degeneration Center, Perelman School of Medicine Department of Neurology Philadelphia Pennsylvania USA.
David J IrwinFrontotemporal Degeneration Center, Perelman School of Medicine Department of Neurology Philadelphia Pennsylvania USA.

Funding

Transgenic Mouse Models of Tau PathologiesP01AG017586 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LEE, VIRGINIA M · 2000 to 2021
$37.3M
UPenn ADCC Biomarker CoreP30AG010124 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DETRE, JOHN A · 1991 to 2020
$35.1M
Research Education ComponentP30AG072979 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DAVID A WOLK · 2021 to 2026
$24.8M
Understanding Environmental Contributions to Heterogeneity in bvFTD.P01AG066597 · NIA · UNIVERSITY OF PENNSYLVANIA · PI David John Irwin, Corey T McMillan · 2020 to 2026
$18.8M
Spreading Tau Pathology in Non-Amnestic Alzheimer's DiseaseR01AG054519 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jeffrey S Phillips · 2018 to 2026
$7.4M
Microscopic and Large-Scale Networks of Molecular Pathology in Frontotemporal Lobar DegenerationR01NS109260 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI IRWIN, DAVID JOHN · 2019 to 2023
$3.8M
Identification of Endophenotypes in the Behavioral-Variant of Frontotemporal DemeK23NS088341 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI IRWIN, DAVID JOHN · 2014 to 2018
$836k
NIA NIH HHS P01 AG017586NIA NIH HHS P01 AG066597NIA NIH HHS P30 AG010124NIA NIH HHS P30 AG072979NIA NIH HHS R01 AG054519NINDS NIH HHS K23 NS088341NINDS NIH HHS R01 NS109260
6 · The paper itself

Abstract

introductionIn primary progressive aphasia (PPA) patients with autopsy-confirmed Alzheimer's disease (AD) or frontotemporal lobar degeneration (FLTD), we tested how the core clinical features of logopenic PPA-naming and repetition-change over time and relate to pathologic burden.

methodsIn PPA with AD (n = 13) or FTLD (n = 16) pathology, Boston Naming Test and Forward Digit Span measured longitudinal naming and repetition; as reference, Mini-Mental State Examination (MMSE) measured global cognition. Pathologic burden in left peri-Sylvian regions was related to longitudinal cognitive decline.

resultsPPA with AD showed greater decline in naming ( DISCUSSION: Unique longitudinal profiles of naming and repetition performance in PPA with AD are related to left peri-Sylvian pathology.

Indexed as

Alzheimer's diseasefrontotemporal lobar degenerationprimary progressive aphasia

Identifiers

PMID34368417
PMCPMC8327471

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.