Evidence map›Paper›PMID 34368352›Full record

ArticleBioMed research international2021

A Permissioned Blockchain-Based Clinical Trial Service Platform to Improve Trial Data Transparency.

Lei Hang, BumHwi Kim, KyuHyung Kim, DoHyeun Kim

RetractedAbstract readRetracted Publication
In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Lei HangShanghai Normal University Tianhua College, Shanghai 201815, China.ORCID https://orcid.org/0000-0002-9336-9274
BumHwi KimDaegu-Gyeongbuk Research Center, Electronics and Telecommunications Research Institute, Daegu 42994, Republic of Korea.
KyuHyung KimDaegu-Gyeongbuk Research Center, Electronics and Telecommunications Research Institute, Daegu 42994, Republic of Korea.
DoHyeun KimDepartment of Computer Engineering, Jeju National University, Jeju 63243, Republic of Korea.ORCID https://orcid.org/0000-0002-3457-2301

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical research faces numerous challenges, from patient enrollment to data privacy concerns and regulatory requirements to spiraling costs. Blockchain technology has the potential to overcome these challenges, thus making clinical trials transparent and enhancing public trust in a fair and open process with all stakeholders because of its distinct features such as data immutability and transparency. This paper proposes a permissioned blockchain platform to ensure clinical data transparency and provides secure clinical trial-related solutions. We explore the core functionalities of blockchain applied to clinical trials and illustrate its general principle concretely. These clinical trial operations are automated using the smart contract, which ensures traceability, prevents a posteriori reconstruction, and securely automates the clinical trial. A web-based user interface is also implemented to visualize the data from the blockchain and ease the interaction with the blockchain network. A proof of concept is implemented on Hyperledger Fabric in the case study of clinical management for multiple clinical trials to demonstrate the designed approach's feasibility. Lastly, the experiment results demonstrate the efficiency and usability of the proposed platform.

Indexed as

BlockchainClinical Trials as TopicComputer SecurityHumansReproducibility of Results

Identifiers

PMID34368352
PMCPMC8346314

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.