Evidence map›Paper›PMID 34368345›Full record

ArticleBioMed research international2021

Protective Effect of Luteolin on D-Galactosamine (D-Gal)/Lipopolysaccharide (LPS) Induced Hepatic Injury by in Mice.

Yiwei Pu, Zhaocong Yang, Xuming Mo

RetractedOpen access · hybridAbstract readRetracted Publication
In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yiwei PuDepartment of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0002-3014-7981
Zhaocong YangDepartment of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0002-2133-2333
Xuming MoDepartment of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0002-2264-6123
Second Affiliated Hospital of Nanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To observe the effects of luteolin on galactosamine (D-Gal)/lipopolysaccharide (LPS) induced liver injury in mice. Male C57BL/6 mice were randomly divided into 4 groups: normal control group, D-GaI/LPS group, D-GaI/LPS + luteolin (Lu, 20 mg/kg), and D-GaI/LPS + luteolin (Lu, 40 mg/kg). Mice in the normal control group and D-GaI/LPS group were given distilled water while other groups were given drugs in 7 days by gavage. 4 hours after the continuous administration, Gal (700 mg/kg) and LPS (10 mg/kg) were injected intraperitoneally. Mice in the normal control group were given the same volume of vegetable oil solution. 24 h after the establishment of the mice model, blood and liver samples were collected. Hematoxylin (HE) staining was used to observe the changes of hepatic histopathology. Alanine aminotransferase (ALT) and glutamic oxalacetic transaminase (AST) in serum, interleukin-6 (IL-6), interleukin-1

Indexed as

Alanine TransaminaseAnimalsAspartate AminotransferasesCytokinesGalactosamineLipopolysaccharidesLiverLuteolinMaleMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinProtective AgentsTranscription Factor RelAAlanine TransaminaseAspartate AminotransferasesCytokinesGalactosamineLipopolysaccharidesLuteolinNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseProtective AgentsTranscription Factor RelA

Identifiers

PMID34368345
PMCPMC8342164
OpenAlexW3186727087

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.