Evidence map›Paper›PMID 34368264›Full record

ReviewFrontiers in cardiovascular medicine2021

Sex Differences in Inflammation During Venous Remodeling of Arteriovenous Fistulae.

Shin Mei Chan, Gabe Weininger, John Langford, Daniel Jane-Wit, Alan Dardik

Abstract readReview
In one paragraph

Review in Frontiers in cardiovascular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
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  8. Review
  9. Article
  10. The rodent models of arteriovenous fistula.Frontiers in cardiovascular medicine · 2024
    Review
  11. Article
  12. Article
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  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shin Mei ChanVascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT, United States.
Gabe WeiningerVascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT, United States.
John LangfordVascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT, United States.
Daniel Jane-WitVascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT, United States.
Alan DardikVascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT, United States.

Funding

Manipulating the matrix to improve arteriovenous fistula patencyR01HL144476 · NHLBI · YALE UNIVERSITY · PI Alan Dardik · 2019 to 2026
$5.6M
Research Training in AnesthesiaT32GM086287 · NIGMS · YALE UNIVERSITY · PI ROBERT SCHONBERGER · 2009 to 2026
$3.7M
NHLBI NIH HHS R01 HL144476NIGMS NIH HHS T32 GM086287
6 · The paper itself

Abstract

Vascular disorders frequently have differing clinical presentations among women and men. Sex differences exist in vascular access for hemodialysis; women have reduced rates of arteriovenous fistula (AVF) maturation as well as fistula utilization compared with men. Inflammation is increasingly implicated in both clinical studies and animal models as a potent mechanism driving AVF maturation, especially in vessel dilation and wall thickening, that allows venous remodeling to the fistula environment to support hemodialysis. Sex differences have long been recognized in arterial remodeling and diseases, with men having increased cardiovascular events compared with pre-menopausal women. Many of these arterial diseases are driven by inflammation that is similar to the inflammation during AVF maturation. Improved understanding of sex differences in inflammation during vascular remodeling may suggest sex-specific vascular therapies to improve AVF success.

Indexed as

androgens sex differences in venous inflammationarteriovenous fistulaeestrogenssex differencesvascular inflammation

Identifiers

PMID34368264
PMCPMC8335484

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.