Evidence map›Paper›PMID 34368238›Full record

ArticleFrontiers in robotics and AI2021

Soft Capsule Magnetic Millirobots for Region-Specific Drug Delivery in the Central Nervous System.

Lamar O Mair, Georges Adam, Sagar Chowdhury, Aaron Davis, Dian R Arifin, Fair M Vassoler, Herbert H Engelhard, Jinxing Li, Xinyao Tang, Irving N Weinberg and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in robotics and AI, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Refillable silicone pump with precise switching for timed therapeutic delivery.Frontiers in bioengineering and biotechnology · 2025
    Article
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  8. In Vivo Imaging of Naked and Microencapsulated Islet Cell Transplantation.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  9. Review
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  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 1 country.

Lamar O MairWeinberg Medical Physics, Inc., North Bethesda, MD, United States.
Georges AdamMulti-Scale Robotics and Automation Lab, School of Mechanical Engineering, Purdue University, West Lafayette, IN, United States.
Sagar ChowdhuryWeinberg Medical Physics, Inc., North Bethesda, MD, United States.
Aaron DavisMulti-Scale Robotics and Automation Lab, School of Mechanical Engineering, Purdue University, West Lafayette, IN, United States.
Dian R ArifinRussel H. Morgan Department of Radiology and Radiological Science, Division of Magnetic Resonance Research, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Fair M VassolerCummings School of Veterinary Medicine, Tufts University, North Grafton, MA, United States.
Herbert H EngelhardAffiliated Neurosurgery Corporation, Chicago, IL, United States.
Jinxing LiDepartment of Biomedical Engineering, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, United States.
Xinyao TangWeinberg Medical Physics, Inc., North Bethesda, MD, United States.
Irving N WeinbergWeinberg Medical Physics, Inc., North Bethesda, MD, United States.
Emily E. EvansDepartment of Physics, Elon University, Elon, NC, United States.
Jeff W M BulteRussel H. Morgan Department of Radiology and Radiological Science, Division of Magnetic Resonance Research, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
David J CappelleriMulti-Scale Robotics and Automation Lab, School of Mechanical Engineering, Purdue University, West Lafayette, IN, United States.
Purdue University West Lafayette · USWeinberg Medical Physics (United States) · USElon University · USJohns Hopkins University · USMichigan State University · USResonance Research (United States) · USTufts University · USUniversity of Illinois Chicago · US

Funding

Dual-mode MRI for in vivo sensing of microcapsule stability and biocompatibilityR01DK106972 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W. · 2015 to 2018
$1.7M
NIDDK NIH HHS R01 DK106972
6 · The paper itself

Abstract

Small soft robotic systems are being explored for myriad applications in medicine. Specifically, magnetically actuated microrobots capable of remote manipulation hold significant potential for the targeted delivery of therapeutics and biologicals. Much of previous efforts on microrobotics have been dedicated to locomotion in aqueous environments and hard surfaces. However, our human bodies are made of dense biological tissues, requiring researchers to develop new microrobotics that can locomote atop tissue surfaces. Tumbling microrobots are a sub-category of these devices capable of walking on surfaces guided by rotating magnetic fields. Using microrobots to deliver payloads to specific regions of sensitive tissues is a primary goal of medical microrobots. Central nervous system (CNS) tissues are a prime candidate given their delicate structure and highly region-specific function. Here we demonstrate surface walking of soft alginate capsules capable of moving on top of a rat cortex and mouse spinal cord

Indexed as

alginate microcapsuledrug deliverymagnetic millirobotrotating magnetic fieldssurface walkers

Identifiers

PMID34368238
PMCPMC8340882
OpenAlexW3186417962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.